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Protein sequence databases.
Journal article

Protein sequence databases.

  • Rebhan M Head Bioinformatics Support, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
  • 2010-03-12
Published in:
  • Methods in molecular biology (Clifton, N.J.). - 2010
Amino Acid Sequence
Animals
Computer Graphics
Data Mining
Databases, Protein
Humans
Internet
Models, Molecular
Molecular Sequence Data
Protein Conformation
Protein Folding
Protein Interaction Mapping
Proteins
Software
Structure-Activity Relationship
Systems Biology
Systems Integration
User-Computer Interface
English Protein sequence databases do not contain just the sequence of the protein itself but also annotation that reflects our knowledge of its function and contributing residues. In this chapter, we will discuss various public protein sequence databases, with a focus on those that are generally applicable. Special attention is paid to issues related to the reliability of both sequence and annotation, as those are fundamental to many questions researchers will ask. Using both well-annotated and scarcely annotated human proteins as examples, it will be shown what information about the targets can be collected from freely available Internet resources and how this information can be used. The results are shown to be summarized in a simple graphical model of the protein's sequence architecture highlighting its structural and functional modules.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/45702
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