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Palmoplantar keratodermas.
Journal article

Palmoplantar keratodermas.

  • Itin PH Department of Dermatology, University of Basel, 4031 Basel, Switzerland. peter.itin@unibas.ch
  • Fistarol SK
  • 2005-02-15
Published in:
  • Clinics in dermatology. - 2005
Biopsy, Needle
Connexins
Desmosomes
Female
Genetic Predisposition to Disease
Humans
Immunohistochemistry
Incidence
Keratins
Keratoderma, Palmoplantar
Keratoderma, Palmoplantar, Diffuse
Male
Prognosis
Risk Assessment
Severity of Illness Index
Sex Distribution
English The palmoplantar skin is a highly specialized tissue which is able to resist mechanical trauma and other physical stress. In recent years the more descriptive classification of keratodermas has switched to an exact molecular genetic view where gene functions are considered. Palmoplantar keratodermas can be separated in the following functional subgroups: disturbed gene fuctions in structural proteins (keratins), cornified envelope (loricrin, transglutaminase), cohesion (plakophilin, desmoplakin, desmoglein1), cell-to-cell communication (connexins), and transmembrane signal transduction (cathepsin C). This review intends to emphasize the typical clinical aspects and symptom complexes associated with palmoplantar keratodermas which enable the astute dermatologist to make a clinical diagnosis. In addition the molecular genetic knowledge on the topic is given which is necessary to confirm the clinical diagnosis.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/4627
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