Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock

Pralong, Gerard; Calandra, Thierry; Glausef, Michel-P; Schellekens, Joop; Verhoef, Jan; Bachmann, Fedor; Kruithof, Egbert K O

doi:10.1055/s-0038-1646614

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Journal article

Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock

Pralong, Gerard The Hematology Laboratory, Department of Medicine, University Hospital, Lausanne, Switzerland
Calandra, Thierry The Hematology Laboratory, Department of Medicine, University Hospital, Lausanne, Switzerland
Glausef, Michel-P The Division of Infectious Diseases, Department of Medicine, University Hospital, Lausanne, Switzerland
Schellekens, Joop The Department of Infectious Diseases, University Hospital Utrecht, The Netherlands
Verhoef, Jan The Department of Infectious Diseases, University Hospital Utrecht, The Netherlands
Bachmann, Fedor The Hematology Laboratory, Department of Medicine, University Hospital, Lausanne, Switzerland
Kruithof, Egbert K O The Hematology Laboratory, Department of Medicine, University Hospital, Lausanne, Switzerland

2018-7-24

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Thrombosis and Haemostasis. - Georg Thieme Verlag KG. - 1989, vol. 61, no. 03, p. 459-462

Hematology

English SummaryThe prognostic value of plasminogen activator inhibitor type 1 (PAI-1) in septic shock was investigated in 52 patients with septic shock. The patients had significantly elevated serum PAI-1 levels with respect to the control group (p = 0.002). In patients not having a rapidly fatal underlying disease, PAI-1 was significantly higher in patients dying within a week after onset of shock than in survivors (median PAI-1: 900 and 307 ng/ml, respectively; p = 0.001). The analysis of the distribution of PAI-1 levels permitted retrospectively to determine a threshold level of PAI-1 which had prognostic significance. Mortality was 71% in patients with serum PAI-1 above 550 ng/ml, whereas only two patients (6%) having a PAI-1 below 550 ng/ml died within a week.Thus, in patients with septic shock, PAI-1 appears to have a strong predictive value as to mortality. This early marker may help the clinician in identifying a subgroup of patients particularly at risk.

Language

English

Open access status

closed

Identifiers

DOI 10.1055/s-0038-1646614
ISSN 0340-6245

Persistent URL

https://sonar.ch/global/documents/46277

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