SPCCTDM, a Catalogue for Analysis of Therapeutic Drug Monitoring Related Contents in the Drug Prescription Information
- Ulrich, Sven Pharmaceutical Consultant, Germany
- Baumann, Pierre University of Lausanne, Switzerland
- Conca, Andreas Regional Hospital of Bolzano, Italy
- Kuss, Hans-Joachim University of Munich, Germany
- Stieffenhofer, Viktoria University of Mainz, Germany
- Hiemke, Christoph University of Mainz, Germany
Published in:
- International Journal of Knowledge Discovery in Bioinformatics. - IGI Global. - 2010, vol. 1, no. 2, p. 1-11
English
Therapeutic drug monitoring (TDM) has consistently been shown to be useful for optimization of drug therapy. For the first time, a method has been developed for the text analysis of TDM in SPCs in that a catalogue SPC-ContentTDM (SPCCTDM) provides a codification of the content of TDM in SPCs. It consists of six structure-related items (dose, adverse drug reactions, drug interactions, overdose, pregnancy/breast feeding, and pharmacokinetics) according to implicit or explicit references to TDM in paragraphs of the SPC, and four theory-guided items according to the information about ranges of plasma concentrations and a recommendation of TDM in the SPC. The catalogue is regarded as valid for the text analysis of SPCs with respect to TDM. It can be used in the comparison of SPCs, in the comparison with medico-scientific evidence and for the estimation of the perception of TDM in SPCs by the reader. Regarding the approach as a model of text mining, it may be extended for evaluation of other aspects reported in SPCs.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.4018/jkdb.2010040101
- ISSN 1947-9115
- Persistent URL
- https://sonar.ch/global/documents/46311
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