Highly Selective Volatile Organic Compounds Breath Analysis Using a Broadly-Tunable Vertical-External-Cavity Surface-Emitting Laser.

Tuzson B; Jágerská J; Looser H; Graf M; Felder F; Fill M; Tappy L; Emmenegger L

doi:10.1021/acs.analchem.6b04511

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Journal article

Highly Selective Volatile Organic Compounds Breath Analysis Using a Broadly-Tunable Vertical-External-Cavity Surface-Emitting Laser.

Tuzson B Laboratory for Air Pollution and Environmental Technology, Swiss Federal Laboratories for Materials Science and Technology (Empa) , 8600 Dübendorf, Switzerland.
Jágerská J Laboratory for Air Pollution and Environmental Technology, Swiss Federal Laboratories for Materials Science and Technology (Empa) , 8600 Dübendorf, Switzerland.
Looser H Institute for Aerosol and Sensor Technology, Fachhochschule Nordwestschweiz (FHNW) , 5210 Windisch, Switzerland.
Graf M Laboratory for Air Pollution and Environmental Technology, Swiss Federal Laboratories for Materials Science and Technology (Empa) , 8600 Dübendorf, Switzerland.
Felder F Camlin Technologies AG , 8005 Zürich, Switzerland.
Fill M Camlin Technologies AG , 8005 Zürich, Switzerland.
Tappy L Faculty of Biology and Medicine, Department of Physiology, Universite de Lausanne (UNIL) , 1005 Lausanne, Switzerland.
Emmenegger L Laboratory for Air Pollution and Environmental Technology, Swiss Federal Laboratories for Materials Science and Technology (Empa) , 8600 Dübendorf, Switzerland.

2017-05-18

Published in:

Analytical chemistry. - 2017

English A broadly tunable mid-infrared vertical-external-cavity surface-emitting laser (VECSEL) is employed in a direct absorption laser spectroscopic setup to measure breath acetone. The large wavelength coverage of more than 30 cm-1 at 3.38 μm allows, in addition to acetone, the simultaneous measurement of isoprene, ethanol, methanol, methane, and water. Despite the severe spectral interferences from water and alcohols, an unambiguous determination of acetone is demonstrated with a precision of 13 ppbv that is achieved after 5 min averaging at typical breath mean acetone levels in synthetic gas samples mimicking human breath.

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