Journal article
Single-Cell Analysis Reveals Heterogeneity of Virus Infection, Pathogenicity, and Host Responses: HIV as a Pioneering Example.
- Brandt L Institute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland; email: Angela.Ciuffi@chuv.ch.
- Cristinelli S Institute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland; email: Angela.Ciuffi@chuv.ch.
- Ciuffi A Institute of Microbiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland; email: Angela.Ciuffi@chuv.ch.
- 2020-09-29
Published in:
- Annual review of virology. - 2020
English
While analyses of cell populations provide averaged information about viral infections, single-cell analyses offer individual consideration, thereby revealing a broad spectrum of diversity as well as identifying extreme phenotypes that can be exploited to further understand the complex virus-host interplay. Single-cell technologies applied in the context of human immunodeficiency virus (HIV) infection proved to be valuable tools to help uncover specific biomarkers as well as novel candidate players in virus-host interactions. This review aims at providing an updated overview of single-cell analyses in the field of HIV and acquired knowledge on HIV infection, latency, and host response. Although HIV is a pioneering example, similar single-cell approaches have proven to be valuable for elucidating the behavior and virus-host interplay in a range of other viruses.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1146/annurev-virology-021820-102458
- PMID 32991268
- Persistent URL
- https://sonar.ch/global/documents/46463
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