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Tor signalling in bugs, brain and brawn.
Journal article

Tor signalling in bugs, brain and brawn.

  • Jacinto E Division of Biochemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
  • Hall MN
  • 2003-02-04
Published in:
  • Nature reviews. Molecular cell biology. - 2003
Animals
Drosophila Proteins
Drosophila melanogaster
Humans
Phosphatidylinositol 3-Kinases
Phosphotransferases (Alcohol Group Acceptor)
Receptor Protein-Tyrosine Kinases
Saccharomyces cerevisiae Proteins
Signal Transduction
Tacrolimus Binding Protein 1A
English TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/4652
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