Time-resolved singlet-oxygen luminescence detection with an efficient and practical semiconductor single-photon detector.

Boso G; Ke D; Korzh B; Bouilloux J; Lange N; Zbinden H

doi:10.1364/BOE.7.000211

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Journal article

Time-resolved singlet-oxygen luminescence detection with an efficient and practical semiconductor single-photon detector.

Boso G Group of Applied Physics, University of Geneva, Chemin de Pinchat 22, Genève 4, CH-1211, Switzerland.
Ke D School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, Genève 4, CH-1211, Switzerland.
Korzh B Group of Applied Physics, University of Geneva, Chemin de Pinchat 22, Genève 4, CH-1211, Switzerland.
Bouilloux J School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, Genève 4, CH-1211, Switzerland.
Lange N School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, Genève 4, CH-1211, Switzerland.
Zbinden H Group of Applied Physics, University of Geneva, Chemin de Pinchat 22, Genève 4, CH-1211, Switzerland.

2016-01-29

Published in:

Biomedical optics express. - 2016

(170.3880) Medical and biological imaging

(170.5180) Photodynamic therapy

(170.6280) Spectroscopy, fluorescence and luminescence

(170.6920) Time-resolved imaging

English In clinical applications, such as PhotoDynamic Therapy, direct singlet-oxygen detection through its luminescence in the near-infrared range (1270 nm) has been a challenging task due to its low emission probability and the lack of suitable single-photon detectors. Here, we propose a practical setup based on a negative-feedback avalanche diode detector that is a viable alternative to the current state-of-the art for different clinical scenarios, especially where geometric collection efficiency is limited (e.g. fiber-based systems, confocal microscopy, scanning systems etc.). The proposed setup is characterized with Rose Bengal as a standard photosensitizer and it is used to measure the singlet-oxygen quantum yield of a new set of photosensitizers for site-selective photodynamic therapy.

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