The effects of green coffee bean extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials.
- Ding F Emergency Department, Harbin fifth hospital, Harbin, Heilongjiang, 150040, China.
- Ma B Cardiovascular Medicine Department, Harbin Fifth Hospital, Harbin, Heilongjiang, 150040, China.
- Nazary-Vannani A Department of Cellular and Molecular Nutrition, Students' Scientific Research Center (SSRC) School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Iran.
- Kord-Varkaneh H Department of Clinical Nutrition and Dietetics, Student Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- Fatahi S Student Research Committee, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
- Papageorgiou M Division of Bone Diseases, Department of Internal Medicine Specialties, Geneva University Hospitals & Faculty of Medicine, Geneva 14, Switzerland.
- Rahmani J Department of Clinical Nutrition and Dietetics, Student Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- Poursoleiman F Department of Clinical Nutrition and Dietetics, Student Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- Júnior Borges do Nascimento I University Hospital and School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
- Li H Cardiovascular Medicine Department, Harbin Fifth Hospital, Harbin, Heilongjiang, 150040, China.
- Han D Cardiovascular Medicine Department, Harbin Fifth Hospital, Harbin, Heilongjiang, 150040, China.
- Wang D Cardiovascular Medicine Department, Harbin Fifth Hospital, Harbin, Heilongjiang, 150040, China. Electronic address: dongmei_7683@sina.com.
- 2019-11-22
Published in:
- Nutrition, metabolism, and cardiovascular diseases : NMCD. - 2020
Green-coffee
HDL
LDL
Lipid profile
Meta-analysis
Triglyceride
Anticholesteremic Agents
Biomarkers
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Coffea
Dietary Supplements
Dyslipidemias
Evidence-Based Medicine
Female
Humans
Male
Plant Extracts
Randomized Controlled Trials as Topic
Seeds
Treatment Outcome
Triglycerides
English
BACKGROUND AND AIM
This systematic review and meta-analysis aimed to assess the effects of green coffee bean extract (GCBE) supplementation on lipid profile in adults.
METHODS AND RESULTS
The PubMed/Medline, Scopus, Web of sciences, and Google Scholar were systematically searched for randomized controlled trials available in English and published before February 2019. The meta-analysis was conducted using fixed effects models, and between-study heterogeneity was assessed by Cochran's Q test and I2. A total of 17 effect sizes were included in the meta-analysis. Combined effect sizes on serum total cholesterol concentrations revealed significant effects of GCBE supplementation on serum total cholesterol [weighted mean difference (WMD): -4.51 mg/dL, 95% confidence interval (CI): -6.89, -2.12, p < 0.001], low density lipoprotein-cholesterol (LDL-C) (WMD: -4.38 mg/dL, 95% CI: -6.44, -2.31, p < 0.001), and high density lipoprotein-cholesterol (HDL-C) (WMD: 2.63 mg/dL, 95% CI: 2.20, 3.07, p < 0.001) compared to controls. Nevertheless, no significant changes were observed in serum triglycerides levels (WMD: -4.34 mg/dL, 95% CI: -9.00, 0.32, p = 0.068).
CONCLUSION
The evidence from available studies suggests that the GCBE supplementation leads to significant reductions in total cholesterol, HDL-C, and LDL-C levels, and has modest, but, non-significant effects on triglycerides levels.
This systematic review and meta-analysis aimed to assess the effects of green coffee bean extract (GCBE) supplementation on lipid profile in adults.
METHODS AND RESULTS
The PubMed/Medline, Scopus, Web of sciences, and Google Scholar were systematically searched for randomized controlled trials available in English and published before February 2019. The meta-analysis was conducted using fixed effects models, and between-study heterogeneity was assessed by Cochran's Q test and I2. A total of 17 effect sizes were included in the meta-analysis. Combined effect sizes on serum total cholesterol concentrations revealed significant effects of GCBE supplementation on serum total cholesterol [weighted mean difference (WMD): -4.51 mg/dL, 95% confidence interval (CI): -6.89, -2.12, p < 0.001], low density lipoprotein-cholesterol (LDL-C) (WMD: -4.38 mg/dL, 95% CI: -6.44, -2.31, p < 0.001), and high density lipoprotein-cholesterol (HDL-C) (WMD: 2.63 mg/dL, 95% CI: 2.20, 3.07, p < 0.001) compared to controls. Nevertheless, no significant changes were observed in serum triglycerides levels (WMD: -4.34 mg/dL, 95% CI: -9.00, 0.32, p = 0.068).
CONCLUSION
The evidence from available studies suggests that the GCBE supplementation leads to significant reductions in total cholesterol, HDL-C, and LDL-C levels, and has modest, but, non-significant effects on triglycerides levels.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/j.numecd.2019.10.002
- PMID 31748178
- Persistent URL
- https://sonar.ch/global/documents/46754
Statistics
Document views: 55
File downloads:
- Full-text: 0