European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).
Egea JInstitute Teofilo Hernando, Department of Pharmacology, School of Medicine. Univerisdad Autonoma de Madrid, Spain.
Fabregat IBellvitge Biomedical Research Institute (IDIBELL) and University of Barcelona (UB), L'Hospitalet, Barcelona, Spain.
Frapart YMLCBPT, UMR 8601 CNRS - Paris Descartes University, Sorbonne Paris Cité, Paris, France.
Ghezzi PBrighton & Sussex Medical School, Brighton, UK.
Görlach AExperimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Kietzmann TFaculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, Oulu, Finland.
Kubaichuk KFaculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, University of Oulu, Oulu, Finland.
Knaus UGConway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
Lopez MGInstitute Teofilo Hernando, Department of Pharmacology, School of Medicine. Univerisdad Autonoma de Madrid, Spain.
Olaso-Gonzalez GDepartment of Physiology, University of Valencia, Spain.
Petry AExperimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Munich, Germany.
Schulz RInstitute of Physiology, JLU Giessen, Giessen, Germany.
Vina JDepartment of Physiology, University of Valencia, Spain.
Winyard PUniversity of Exeter Medical School, St Luke's Campus, Exeter EX1 2LU, UK.
Abbas KLCBPT, UMR 8601 CNRS - Paris Descartes University, Sorbonne Paris Cité, Paris, France.
Ademowo OSLife & Health Sciences and Aston Research Centre for Healthy Ageing, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Afonso CBSchool of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B47ET, UK.
Andreadou ILaboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece.
Antelmann HInstitute for Biology-Microbiology, Freie Universität Berlin, Berlin, Germany.
Antunes FDepartamento de Química e Bioquímica and Centro de Química e Bioquímica, Faculdade de Ciências, Portugal.
Aslan MDepartment of Medical Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
Bachschmid MMVascular Biology Section & Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Barbosa RMCenter for Neurosciences and Cell Biology, University of Coimbra and Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Belousov VMolecular technologies laboratory, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow 117997, Russia.
Berndt CDepartment of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Bernlohr DDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota - Twin Cities, USA.
Bertrán EBellvitge Biomedical Research Institute (IDIBELL) and University of Barcelona (UB), L'Hospitalet, Barcelona, Spain.
Bindoli AInstitute of Neuroscience (CNR), Padova, Italy.
Bottari SPGETI, Institute for Advanced Biosciences, INSERM U1029, CNRS UMR 5309, Grenoble-Alpes University and Radio-analysis Laboratory, CHU de Grenoble, Grenoble, France.
Brito PMResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal; Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.
Carrara GDepartment of Pathology, University of Cambridge, Cambridge, UK.
Casas AIDepartment of Pharmacology & Personalized Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Chatzi AInstitute of Molecular Cell and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, University Avenue, Glasgow, UK.
Chondrogianni NNational Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.
Conrad MHelmholtz Center Munich, Institute of Developmental Genetics, Neuherberg, Germany.
Cooke MSOxidative Stress Group, Dept. Environmental & Occupational Health, Florida International University, Miami, FL 33199, USA.
Costa JGResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal; CBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Lisboa, Portugal.
Cuadrado AInstituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC, Instituto de Investigación Sanitaria La Paz (IdiPaz), Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
My-Chan Dang PUniversité Paris Diderot, Sorbonne Paris Cité, INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Paris, France.
De Smet BDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium; Structural Biology Research Center, VIB, 1050 Brussels, Belgium; Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Padova, Italy; Pharmahungary Group, Szeged, Hungary.
Debelec-Butuner BDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, Ege University, Bornova, Izmir 35100, Turkey.
Dias IHKLife & Health Sciences and Aston Research Centre for Healthy Ageing, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Dunn JDDepartment of Biochemistry, Science II, University of Geneva, 30 quai Ernest-Ansermet, 1211 Geneva-4, Switzerland.
Edson AJDepartment of Molecular Biology, University of Bergen, Bergen, Norway.
El Assar MFundación para la Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain.
El-Benna JUniversité Paris Diderot, Sorbonne Paris Cité, INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, Laboratoire d'Excellence Inflamex, Faculté de Médecine Xavier Bichat, Paris, France.
Ferdinandy PDepartment of Pharmacology and Pharmacotherapy, Medical Faculty, Semmelweis University, Budapest, Hungary; Pharmahungary Group, Szeged, Hungary.
Fernandes ASCBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Lisboa, Portugal.
Fladmark KEDepartment of Molecular Biology, University of Bergen, Bergen, Norway.
Förstermann UDepartment of Pharmacology, Johannes Gutenberg University Medical Center, Mainz, Germany.
Giniatullin RA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Giricz ZDepartment of Pharmacology and Pharmacotherapy, Medical Faculty, Semmelweis University, Budapest, Hungary; Pharmahungary Group, Szeged, Hungary.
Görbe ADepartment of Pharmacology and Pharmacotherapy, Medical Faculty, Semmelweis University, Budapest, Hungary; Pharmahungary Group, Szeged, Hungary.
Griffiths HLife & Health Sciences and Aston Research Centre for Healthy Ageing, Aston University, Aston Triangle, Birmingham B4 7ET, UK; Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
Hampl VDepartment of Physiology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
Hanf AMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Herget JDepartment of Physiology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
Hernansanz-Agustín PServicio de Immunología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain; Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas Alberto Sols, Madrid, Spain.
Hillion MInstitute for Biology-Microbiology, Freie Universität Berlin, Berlin, Germany.
Huang JDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium; Structural Biology Research Center, VIB, 1050 Brussels, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; Brussels Center for Redox Biology, Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Ilikay SHarran University, Arts and Science Faculty, Department of Biology, Cancer Biology Lab, Osmanbey Campus, Sanliurfa, Turkey.
Jansen-Dürr PInstitute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.
Jaquet VDept. of Pathology and Immunology, Centre Médical Universitaire, Geneva, Switzerland.
Joles JADepartment of Nephrology & Hypertension, University Medical Center Utrecht, The Netherlands.
Kalyanaraman BMedical College of Wisconsin, Milwaukee, USA.
Kaminskyy DDanylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Karbaschi MOxidative Stress Group, Dept. Environmental & Occupational Health, Florida International University, Miami, FL 33199, USA.
Kleanthous MMolecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Klotz LOInstitute of Nutrition, Department of Nutrigenomics, Friedrich Schiller University, Jena, Germany.
Korac BUniversity of Belgrade, Institute for Biological Research "Sinisa Stankovic" and Faculty of Biology, Belgrade, Serbia.
Korkmaz KSDepartment of Bioengineering, Cancer Biology Laboratory, Faculty of Engineering, Ege University, Bornova, 35100 Izmir, Turkey.
Koziel RInstitute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.
Kračun DExperimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Munich, Germany.
Krause KHDept. of Pathology and Immunology, Centre Médical Universitaire, Geneva, Switzerland.
Křen VInstitute of Microbiology, Laboratory of Biotransformation, Czech Academy of Sciences, Videnska 1083, CZ-142 20 Prague, Czech Republic.
Krieg TDepartment of Medicine, University of Cambridge, UK.
Laranjinha JCenter for Neurosciences and Cell Biology, University of Coimbra and Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Lazou ASchool of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Li HDepartment of Pharmacology, Johannes Gutenberg University Medical Center, Mainz, Germany.
Martínez-Ruiz AServicio de Immunología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Matsui RVascular Biology Section & Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
McBean GJSchool of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland.
Meredith SPSchool of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B47ET, UK.
Messens JStructural Biology Research Center, VIB, 1050 Brussels, Belgium; Brussels Center for Redox Biology, Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Miguel VCentro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Madrid, Spain.
Mikhed YMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Milisav IUniversity of Ljubljana, Faculty of Medicine, Institute of Pathophysiology and Faculty of Health Sciences, Ljubljana, Slovenia.
Milković LRuđer Bošković Institute, Division of Molecular Medicine, Zagreb, Croatia.
Miranda-Vizuete AInstituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Mojović MUniversity of Belgrade, Faculty of Physical Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
Monsalve MInstituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), Madrid, Spain.
Mouthuy PALaboratory for Oxidative Stress, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia.
Mulvey JDepartment of Medicine, University of Cambridge, UK.
Münzel TMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Muzykantov VDepartment of Pharmacology, Center for Targeted Therapeutics & Translational Nanomedicine, ITMAT/CTSA Translational Research Center University of Pennsylvania The Perelman School of Medicine, Philadelphia, PA, USA.
Nguyen ITNDepartment of Nephrology & Hypertension, University Medical Center Utrecht, The Netherlands.
Oelze MMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Oliveira NGResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal.
Palmeira CMCenter for Neurosciences & Cell Biology of the University of Coimbra, Coimbra, Portugal; Department of Life Sciences of the Faculty of Sciences & Technology of the University of Coimbra, Coimbra, Portugal.
Papaevgeniou NNational Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., 116 35 Athens, Greece.
Pavićević AUniversity of Belgrade, Faculty of Physical Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
Pedre BStructural Biology Research Center, VIB, 1050 Brussels, Belgium; Brussels Center for Redox Biology, Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
Peyrot FLCBPT, UMR 8601 CNRS - Paris Descartes University, Sorbonne Paris Cité, Paris, France; ESPE of Paris, Paris Sorbonne University, Paris, France.
Phylactides MMolecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Pircalabioru GGThe Research Institute of University of Bucharest, Bucharest, Romania.
Pitt ARSchool of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B47ET, UK.
Poulsen HELaboratory of Clinical Pharmacology, Rigshospitalet, University Hospital Copenhagen, Denmark; Department of Clinical Pharmacology, Bispebjerg Frederiksberg Hospital, University Hospital Copenhagen, Denmark; Department Q7642, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
Prieto IInstituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), Madrid, Spain.
Rigobello MPDepartment of Biomedical Sciences, University of Padova, via Ugo Bassi 58/b, 35131 Padova, Italy.
Robledinos-Antón NInstituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC, Instituto de Investigación Sanitaria La Paz (IdiPaz), Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Rodríguez-Mañas LFundación para la Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain; Servicio de Geriatría, Hospital Universitario de Getafe, Getafe, Spain.
Rolo APCenter for Neurosciences & Cell Biology of the University of Coimbra, Coimbra, Portugal; Department of Life Sciences of the Faculty of Sciences & Technology of the University of Coimbra, Coimbra, Portugal.
Rousset FDept. of Pathology and Immunology, Centre Médical Universitaire, Geneva, Switzerland.
Ruskovska TFaculty of Medical Sciences, Goce Delcev University, Stip, Republic of Macedonia.
Saraiva NCBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Lisboa, Portugal.
Sasson SInstitute for Drug Research, Section of Pharmacology, Diabetes Research Unit, The Hebrew University Faculty of Medicine, Jerusalem, Israel.
Schröder KInstitute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhine-Main, Mainz, Germany.
Semen KDanylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Seredenina TDept. of Pathology and Immunology, Centre Médical Universitaire, Geneva, Switzerland.
Shakirzyanova AA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Smith GLDepartment of Pathology, University of Cambridge, Cambridge, UK.
Soldati TDepartment of Biochemistry, Science II, University of Geneva, 30 quai Ernest-Ansermet, 1211 Geneva-4, Switzerland.
Sousa BCSchool of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B47ET, UK.
Spickett CMLife & Health Sciences and Aston Research Centre for Healthy Ageing, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Stancic AUniversity of Belgrade, Institute for Biological Research "Sinisa Stankovic" and Faculty of Biology, Belgrade, Serbia.
Steinbrenner HInstitute of Nutrition, Department of Nutrigenomics, Friedrich Schiller University, Jena, Germany.
Stepanić VRuđer Bošković Institute, Division of Molecular Medicine, Zagreb, Croatia.
Steven SMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.
Tokatlidis KInstitute of Molecular Cell and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, University Avenue, Glasgow, UK.
Tuncay EDepartment of Biophysics, Ankara University, Faculty of Medicine, 06100 Ankara, Turkey.
Turan BDepartment of Biophysics, Ankara University, Faculty of Medicine, 06100 Ankara, Turkey.
Ursini FDepartment of Molecular Medicine, University of Padova, Padova, Italy.
Vacek JDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hnevotinska 3, Olomouc 77515, Czech Republic.
Vajnerova ODepartment of Physiology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
Valentová KInstitute of Microbiology, Laboratory of Biotransformation, Czech Academy of Sciences, Videnska 1083, CZ-142 20 Prague, Czech Republic.
Van Breusegem FDepartment of Plant Systems Biology, VIB, 9052 Ghent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
Varisli LHarran University, Arts and Science Faculty, Department of Biology, Cancer Biology Lab, Osmanbey Campus, Sanliurfa, Turkey.
Veal EAInstitute for Cell and Molecular Biosciences, and Institute for Ageing, Newcastle University, Framlington Place, Newcastle upon Tyne, UK.
Yalçın ASDepartment of Biochemistry, School of Medicine, Marmara University, İstanbul, Turkey.
Yelisyeyeva ODanylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Žarković NLaboratory for Oxidative Stress, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia.
Zatloukalová MDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hnevotinska 3, Olomouc 77515, Czech Republic.
Zielonka JMedical College of Wisconsin, Milwaukee, USA.
Touyz RMInstitute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
Papapetropoulos ALaboratoty of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece.
Grune TGerman Institute of Human Nutrition, Department of Toxicology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Lamas SCentro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Madrid, Spain.
Schmidt HHHWDepartment of Pharmacology & Personalized Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Di Lisa FDepartment of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Padova, Italy. Electronic address: dilisa@bio.unipd.it.
Daiber AMolecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhine-Main, Mainz, Germany. Electronic address: daiber@uni-mainz.de.
English
The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.