Enhancement of the oral absorption of cyclosporin in man.
- Drewe J Department of Anesthesia and Research, University of Basel, Switzerland.
- Meier R
- Vonderscher J
- Kiss D
- Posanski U
- Kissel T
- Gyr K
- 1992-07-01
Published in:
- British journal of clinical pharmacology. - 1992
Administration, Oral
Adult
Capsules
Cyclosporine
Emulsions
Humans
Intestinal Absorption
Male
Random Allocation
English
1. The oral absorption of cyclosporin from three new semi-solid oral formulations was compared with the standard soft gelatine preparation in twelve healthy male volunteers. One formulation was based on a solid micellar solution, while the other two, with different in vitro release properties, were based on a microemulsion principle. 2. The results showed that the solid micellar solution and the faster releasing microemulsion formulation increased the extent of absorption on average by 45.2 and 49.0%, respectively, compared with the reference soft gelatine capsule.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1111/j.1365-2125.1992.tb04108.x
- PMID 1633069
- Persistent URL
- https://sonar.ch/global/documents/46977
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