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Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse.
Journal article

Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse.

  • 2002-03-14
Published in:
  • Developmental dynamics : an official publication of the American Association of Anatomists. - 2002
Age Factors
Animals
DNA-Binding Proteins
Early Growth Response Protein 1
Early Growth Response Protein 2
Galactosides
Genes, Immediate-Early
Genotype
Immediate-Early Proteins
In Situ Hybridization
Indoles
Mesoderm
Mice
Mice, Transgenic
Microscopy, Electron, Scanning
Polymerase Chain Reaction
Signal Transduction
Time Factors
Transcription Factors
Up-Regulation
Wound Healing
English Embryos show a remarkable capacity for perfect repair after injury. Wounding of embryonic skin triggers rapid activation of epithelial sweeping and mesenchymal contraction tissue movements that bear striking analogy to several naturally occurring morphogenetic tissue movements, but very little is known about the early molecular signals that might initiate such movements. Here, we describe the rapid and transient up-regulation of two immediate early genes, krox-24 and krox-20, after wounding of the embryonic mouse. Furthermore, we demonstrate that these signals are conserved, but of longer duration, in the neonate and adult wound situation. To further test the roles of these transcription factors in vivo, we performed wound healing studies on embryos lacking either Krox-24 or 20. Despite the dramatic up-regulation of these genes in response to injury, our studies reveal that neither of them on their own is essential for repair.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/47037
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