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Dependence of acetylcholine receptor channel conversion on muscle activity at denervated neonatal rat endplates.
Journal article

Dependence of acetylcholine receptor channel conversion on muscle activity at denervated neonatal rat endplates.

  • Brenner HR Department of Physiology, University of Basel, Switzerland.
  • 1988-05-26
Published in:
  • Neuroscience letters. - 1988
Action Potentials
Animals
Animals, Newborn
Bungarotoxins
Electric Stimulation
Ion Channels
Motor Endplate
Muscle Denervation
Muscle Development
Muscles
Neuromuscular Junction
Rats
Rats, Inbred Strains
Receptors, Cholinergic
English During the development of the motor endplate, the apparent mean open time of the junctional acetylcholine (AChR) channels decreases during the first 3 weeks of postnatal life from about 4 to about 1 ms. This decrease is prevented by early denervation of the muscle, suggesting a neural control of subsynaptic AChR channel properties. To further examine the nature of this neural influence, neonatal rat soleus muscles were now denervated at an early stage of endplate development and the muscles were kept active by chronic stimulations in vivo for 4 days. The gating properties of AChR channels at the denervated endplates and at control endplates of similar age were then examined by analysis of acetylcholine-induced endplate current fluctuations and of the time course of miniature endplate currents, respectively. The results indicate, that stimulation restores the maturation of 'adult' AChR channel properties even in the absence of the nerve, suggesting an important role of muscle activity in synapse development.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/47046
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