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Compounds binding to cytoskeletal proteins are active against Plasmodium falciparum in vitro.
Journal article

Compounds binding to cytoskeletal proteins are active against Plasmodium falciparum in vitro.

  • 1989-05-01
Published in:
  • Cell biology international reports. - 1989
Actins
Albendazole
Animals
Anthelmintics
Antimalarials
Antineoplastic Agents
Benzimidazoles
Cytochalasin B
Cytoskeletal Proteins
Demecolcine
Dioxolanes
Drug Resistance
Erythrocytes
Humans
Mebendazole
Nocodazole
Plasmodium falciparum
Tubulin
Vinblastine
Vincristine
English The effects of nine different tubulin-binding substances and of one actin-binding compound, cytochalasin B, upon the intraerythrocytic development of the malaria parasite Plasmodium falciparum were investigated in vitro. From the data obtained, plasmodial tubulins seem to be quite different from the mammalian proteins on the molecular level. Tubulozole-T, a substance which is inactive in mammalian systems, appears to be a promising novel antimalarial drug.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/47059
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