Journal article
Highly enantioselective hydrolysis of alicyclic meso-epoxides with a bacterial epoxide hydrolase from Sphingomonas sp. HXN-200: simple syntheses of alicyclic vicinal trans-diols.
- Chang D Institute of Biotechnology, Swiss Federal Institute of Technology Zurich, ETH-Hoenggerberg, CH-8093 Zurich, Switzerland.
- Wang Z
- Heringa MF
- Wirthner R
- Witholt B
- Li Z
- 2003-05-15
Published in:
- Chemical communications (Cambridge, England). - 2003
Alcohols
Cyclohexanes
Cyclohexenes
Epoxide Hydrolases
Epoxy Compounds
Hydrocarbons, Alicyclic
Hydrolysis
Pyrrolidines
Sphingomonas
Stereoisomerism
English
Hydrolysis of N-benzyloxycarbonyl-3,4-epoxy-pyrrolidine and cyclohexene oxide with the epoxide hydrolase of Sphingomonas sp. HXN-200, respectively, gave the corresponding vicinal trans-diols in high ee and yield, representing the first example of enantioselective hydrolysis of a meso-epoxide with a bacterial epoxide hydrolase.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1039/b300435j
- PMID 12744319
- Persistent URL
- https://sonar.ch/global/documents/47092
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