Journal article
Fatigue in inflammatory bowel disease and its impact on daily activities.
- Schreiner P Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland.
- Rossel JB Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne.
- Biedermann L Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland.
- Valko PO Department of Neurology, University Hospital of Zurich, Zurich, Switzerland.
- Baumann CR Department of Neurology, University Hospital of Zurich, Zurich, Switzerland.
- Greuter T Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland.
- Scharl M Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland.
- Vavricka SR Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland.
- Pittet V Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne.
- Juillerat P Department of Visceral Surgery and Medicine, Inselspital Bern University Hospital, Bern University, Bern, Switzerland.
- Rogler G Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland.
- von Känel R Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
- Misselwitz B Department of Gastroenterology & Hepatology, University Hospital Zurich, Zurich, Switzerland.
- 2020-11-07
Published in:
- Alimentary pharmacology & therapeutics. - 2020
English
BACKGROUND
Fatigue is a common symptom of chronic inflammation, including inflammatory bowel disease (IBD), resulting in significant impairment in quality of life.
AIMS
To identify the prevalence of fatigue in a large IBD cohort compared to the general population, address risk factors, and evaluate its impact on daily life.
METHODS
We evaluated 1208 IBD patients from the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) and 414 healthy controls. Significant fatigue was defined as a visual analogue scale (VAS-F, range 0-10) score ≥ 4. Secondary endpoints were severity of fatigue and its impact on daily activities with the Fatigue Severity Scale (FSS), with a score ≥ 4 indicative of fatigue. Demographic, IBD-related and psychiatric symptoms were assessed with a multivariate analysis of variance (MANOVA) model optimised for prediction of VAS-F (primary outcome) and FSS scores.
RESULTS
Overall, 672 IBD patients (55.6%) reported significant fatigue compared to 145 (35%) controls (OR 2.71; 95% CI 2.08-3.54; P < 0.001). In IBD, fatigue also significantly affected daily activities (FSS ≥ 4; 405 (33.5%) IBD patients vs 81 (19.6%) controls, P < 0.001). In the MANOVA model, fatigue levels were associated with female gender (coefficient 0.839; 0.556 - 1.123; P < 0.001), younger age at diagnosis (-0.031 per year; -0.042- -0.019; P < 0.001), shorter disease duration (-0.036 per year; -0.050- -0.022; P < 0.001), nocturnal diarrhoea (0.718; 0.295-1.141; P = 0.001), low educational level (P = 0.034) and symptoms of depression and anxiety.
CONCLUSIONS
Fatigue is both more frequent and more severe in patients with IBD than in the general population.
Fatigue is a common symptom of chronic inflammation, including inflammatory bowel disease (IBD), resulting in significant impairment in quality of life.
AIMS
To identify the prevalence of fatigue in a large IBD cohort compared to the general population, address risk factors, and evaluate its impact on daily life.
METHODS
We evaluated 1208 IBD patients from the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) and 414 healthy controls. Significant fatigue was defined as a visual analogue scale (VAS-F, range 0-10) score ≥ 4. Secondary endpoints were severity of fatigue and its impact on daily activities with the Fatigue Severity Scale (FSS), with a score ≥ 4 indicative of fatigue. Demographic, IBD-related and psychiatric symptoms were assessed with a multivariate analysis of variance (MANOVA) model optimised for prediction of VAS-F (primary outcome) and FSS scores.
RESULTS
Overall, 672 IBD patients (55.6%) reported significant fatigue compared to 145 (35%) controls (OR 2.71; 95% CI 2.08-3.54; P < 0.001). In IBD, fatigue also significantly affected daily activities (FSS ≥ 4; 405 (33.5%) IBD patients vs 81 (19.6%) controls, P < 0.001). In the MANOVA model, fatigue levels were associated with female gender (coefficient 0.839; 0.556 - 1.123; P < 0.001), younger age at diagnosis (-0.031 per year; -0.042- -0.019; P < 0.001), shorter disease duration (-0.036 per year; -0.050- -0.022; P < 0.001), nocturnal diarrhoea (0.718; 0.295-1.141; P = 0.001), low educational level (P = 0.034) and symptoms of depression and anxiety.
CONCLUSIONS
Fatigue is both more frequent and more severe in patients with IBD than in the general population.
- Language
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- English
- Identifiers
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- DOI 10.1111/apt.16145
- PMID 33159475
- Persistent URL
- https://sonar.ch/global/documents/47106
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