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T-cell fate and function: PKC-theta and beyond.
Journal article

T-cell fate and function: PKC-theta and beyond.

  • Marsland BJ Institute of Integrative Biology, Molecular Biomedicine, Swiss Federal Institute of Technology ETH, CH-8952 Zurich, Switzerland. marsland@env.ethz.ch
  • Kopf M
  • 2008-03-11
Published in:
  • Trends in immunology. - 2008
Animals
Antigen-Presenting Cells
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Differentiation
Cell Proliferation
Cytokines
Gap Junctions
Lymphocyte Activation
Protein Kinase C
Receptors, Antigen, T-Cell
Signal Transduction
T-Lymphocytes, Regulatory
Th1 Cells
Th2 Cells
English The serine/threonine-specific protein kinase C-theta (PKC-theta) is a core component of the immunological synapse that was shown in vitro to play a central role in the activation of T cells after T cell receptor (TCR) and co-stimulatory molecule engagement. In recent years, a series of in vivo studies have shown that the situation is far more complex; specifically, PKC-theta signaling is differentially required for Th1, Th2, Th17 and CD8+ cytotoxic T-cell responses. These studies highlight the combination of signals that directly regulate T-cell differentiation and effector responses. In this review, we highlight recent in vivo studies investigating PKC-theta function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/47178
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