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Lewis acid-Lewis base catalyzed enantioselective hetero-Diels-Alder reaction for direct access to delta-lactones.
Journal article

Lewis acid-Lewis base catalyzed enantioselective hetero-Diels-Alder reaction for direct access to delta-lactones.

  • Tiseni PS ETH Zürich, Laboratory of Organic Chemistry, Wolfgang-Pauli-Str. 10, Hönggerberg HCI E 111, CH-8093 Zürich, Switzerland.
  • Peters R
  • 2008-04-24
Published in:
  • Organic letters. - 2008
Catalysis
Cyclization
Erbium
Lactones
Ligands
Molecular Structure
Organometallic Compounds
Stereoisomerism
English A complex formed in situ from Er(OTf)3 and a simple commercially available norephedrine ligand promotes an unprecedented [4 + 2] cycloaddition of alpha,beta-unsaturated acid chlorides with a broad range of aromatic and heteroaromatic aldehydes by a cooperative bifunctional Lewis acid-Lewis base catalytic mode of action providing valuable delta-lactone building blocks with excellent enantioselectivity.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/47186
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