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Inhibition of Nogo: a key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system.
Journal article

Inhibition of Nogo: a key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system.

  • Buchli AD Brain Research Institute, University of Zurich and Department of Biology, Swiss Federal Institute of Technology-Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
  • Schwab ME
  • 2005-12-13
Published in:
  • Annals of medicine. - 2005
Animals
Antibodies, Monoclonal
Axons
Central Nervous System Diseases
Disease Models, Animal
Growth Inhibitors
Humans
Myelin Proteins
Nerve Regeneration
Neuronal Plasticity
Nogo Proteins
Recovery of Function
Xenopus Proteins
English In the adult central nervous system (CNS) myelin and oligodendrocytes, Nogo-A exerts a growth inhibitory function leading to restricted axonal regeneration. After development of different anti-Nogo-A antibodies and other Nogo-A blocking reagents their application has recently been studied in various in vivo animal models of spinal cord injury and stroke. These studies show that intracerebral application of Nogo-A-inactivating reagents leads to enhanced regeneration and compensatory sprouting, structural reorganization or plasticity, and functional recovery as seen in different behavioural analyses.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/47236
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