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Models to explain dose-response relationships that exhibit a downturn phase.
Journal article

Models to explain dose-response relationships that exhibit a downturn phase.

  • Pliska V ETH Zürich Department of Animal Science, Switzerland.
  • 1994-06-01
Published in:
  • Trends in pharmacological sciences. - 1994
Algorithms
Animals
Dose-Response Relationship, Drug
Female
Models, Biological
Natriuresis
Oxytocin
Rats
Uterus
Vasotocin
English Over a broad dose (or concentration) range, dose-response relationships frequently display a bell-shaped form. Mechanisms leading to this phenomenon may be manifold, but so far they have not been adequately identified. In this article, Vladimir Pliska discusses two models that are based on multiple-state cell-signaling pathways and enable an estimate of generally applicable descriptors. These can be used for expression of drug potency and for similar purposes.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/47405
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