Journal article
Structural and perfusion magnetic resonance imaging of the lung in cystic fibrosis.
- Amaxopoulou C Department of Diagnostic Imaging, University Children's Hospital Zürich, Steinwiesstr. 75, 8032, Zürich, CH, Switzerland. christina.amaxopoulou@gmail.com.
- Gnannt R Department of Diagnostic Imaging, University Children's Hospital Zürich, Steinwiesstr. 75, 8032, Zürich, CH, Switzerland.
- Higashigaito K Institute of Diagnostic and Interventional Radiology, University Hospital Zürich, Zürich, Switzerland.
- Jung A Children's Research Center, University Children's Hospital Zürich, Zürich, Switzerland.
- Kellenberger CJ Department of Diagnostic Imaging, University Children's Hospital Zürich, Steinwiesstr. 75, 8032, Zürich, CH, Switzerland.
- 2017-11-17
Published in:
- Pediatric radiology. - 2018
Adolescents
Children
Cystic fibrosis
Functional magnetic resonance imaging
Lung
Perfusion imaging
Adolescent
Child
Child, Preschool
Contrast Media
Cystic Fibrosis
Female
Humans
Infant
Lung
Magnetic Resonance Imaging
Male
Meglumine
Organometallic Compounds
Respiratory-Gated Imaging Techniques
Retrospective Studies
Young Adult
English
BACKGROUND
Because of its absence of ionising radiation and possibility for obtaining functional information, MRI is promising for assessing lung disease in children who require repetitive imaging for long-term follow-up.
OBJECTIVE
To describe MRI findings in children with cystic fibrosis and evaluate semi-quantitative dynamic contrast-enhanced lung perfusion.
MATERIALS AND METHODS
We retrospectively compared lung MRI in 25 children and young adults with cystic fibrosis (median age 3.7 years) to 12 children (median age 2 years) imaged for other pathologies. MRI at 1.5 T included respiratory-gated sequences and contrast-enhanced lung perfusion imaging. We described and graded any morphologic change. Signal enhancement and time to peak values of perfusion abnormalities were compared to those of normally enhancing lung parenchyma.
RESULTS
Frequent findings in patients with cystic fibrosis were bronchial wall thickening (24/25, 96%), areas of consolidation (22/25, 88%), enlarged lymph nodes (20/25, 80%), bronchiectasis (5/25, 20%) and mucus plugging (3/25, 12%). Compared to normally enhancing lung, perfusion defects (21/25, 84%), characterised by decreased enhancement, showed prolonged time to peak. Areas of consolidation showed increased enhancement. While time to peak of procedure-related atelectasis was not significantly different from that of normal lung, disease-related consolidation showed prolonged time to peak (P=0.01).
CONCLUSION
Lung MRI demonstrates structural and perfusion abnormalities in children and young people with cystic fibrosis. Semi-quantitative assessment of dynamic contrast-enhanced perfusion imaging might allow differentiation between procedure-related atelectasis and disease-related consolidation.
Because of its absence of ionising radiation and possibility for obtaining functional information, MRI is promising for assessing lung disease in children who require repetitive imaging for long-term follow-up.
OBJECTIVE
To describe MRI findings in children with cystic fibrosis and evaluate semi-quantitative dynamic contrast-enhanced lung perfusion.
MATERIALS AND METHODS
We retrospectively compared lung MRI in 25 children and young adults with cystic fibrosis (median age 3.7 years) to 12 children (median age 2 years) imaged for other pathologies. MRI at 1.5 T included respiratory-gated sequences and contrast-enhanced lung perfusion imaging. We described and graded any morphologic change. Signal enhancement and time to peak values of perfusion abnormalities were compared to those of normally enhancing lung parenchyma.
RESULTS
Frequent findings in patients with cystic fibrosis were bronchial wall thickening (24/25, 96%), areas of consolidation (22/25, 88%), enlarged lymph nodes (20/25, 80%), bronchiectasis (5/25, 20%) and mucus plugging (3/25, 12%). Compared to normally enhancing lung, perfusion defects (21/25, 84%), characterised by decreased enhancement, showed prolonged time to peak. Areas of consolidation showed increased enhancement. While time to peak of procedure-related atelectasis was not significantly different from that of normal lung, disease-related consolidation showed prolonged time to peak (P=0.01).
CONCLUSION
Lung MRI demonstrates structural and perfusion abnormalities in children and young people with cystic fibrosis. Semi-quantitative assessment of dynamic contrast-enhanced perfusion imaging might allow differentiation between procedure-related atelectasis and disease-related consolidation.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/s00247-017-4021-8
- PMID 29143200
- Persistent URL
- https://sonar.ch/global/documents/47411
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