Back
Full-text
Journal article

Rapid adaptation to microgravity in mammalian macrophage cells.

  • Thiel CS Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. cora.thiel@uzh.ch.
  • de Zélicourt D Institute of Physiology, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Tauber S Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Adrian A Airbus Defence and Space, GmbH, Claude-Dornier-Strasse, 88090, Immenstaad, Germany.
  • Franz M Airbus Defence and Space, GmbH, Claude-Dornier-Strasse, 88090, Immenstaad, Germany.
  • Simmet DM Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Schoppmann K Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Hauschild S Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Krammer S Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Christen M Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Bradacs G Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Paulsen K Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Wolf SA Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Braun M German Aerospace Center (DLR), Space Agency, Königswinterer Strasse 522-524, 53227, Bonn, Germany.
  • Hatton J European Space Agency (ESA), Keplerlaan 1, 2201, AZ, Noordwijk, Netherlands.
  • Kurtcuoglu V Institute of Physiology, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Franke S German Aerospace Center (DLR), Linder Hoehe, 51147, Cologne, Germany.
  • Tanner S BIOTESC, CC Aerospace Biomedical Science and Technology, Lucerne School of Engineering and Architecture, Technikumstrasse 21, 6048, Horw, Switzerland.
  • Cristoforetti S European Space Agency (ESA), Keplerlaan 1, 2201, AZ, Noordwijk, Netherlands.
  • Sick B Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland.
  • Hock B Chair of Proteomics and Bioanalytics, Technical University of Munich, Alte Akademie 14, 85354, Freising, Germany.
  • Ullrich O Institute of Anatomy, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland. oliver.ullrich@uzh.ch.
Show more…
  • 2017-03-01
Published in:
  • Scientific reports. - 2017
Adaptation, Physiological
Animals
Cell Line
Macrophages, Alveolar
Rats
Respiratory Burst
Space Flight
Weightlessness
English Despite the observed severe effects of microgravity on mammalian cells, many astronauts have completed long term stays in space without suffering from severe health problems. This raises questions about the cellular capacity for adaptation to a new gravitational environment. The International Space Station (ISS) experiment TRIPLE LUX A, performed in the BIOLAB laboratory of the ISS COLUMBUS module, allowed for the first time the direct measurement of a cellular function in real time and on orbit. We measured the oxidative burst reaction in mammalian macrophages (NR8383 rat alveolar macrophages) exposed to a centrifuge regime of internal 0 g and 1 g controls and step-wise increase or decrease of the gravitational force in four independent experiments. Surprisingly, we found that these macrophages adapted to microgravity in an ultra-fast manner within seconds, after an immediate inhibitory effect on the oxidative burst reaction. For the first time, we provided direct evidence of cellular sensitivity to gravity, through real-time on orbit measurements and by using an experimental system, in which all factors except gravity were constant. The surprisingly ultra-fast adaptation to microgravity indicates that mammalian macrophages are equipped with a highly efficient adaptation potential to a low gravity environment. This opens new avenues for the exploration of adaptation of mammalian cells to gravitational changes.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/47476
Statistics
Document views: 41 File downloads:
  • Full-text: 0