Journal article
Cardiovascular effects of two adenosine constant rate infusions in anaesthetized dogs.
- Joerger FB Department of Clinical Diagnostics and Services, Division of Anaesthesiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland. Electronic address: fjoerger@vetclinics.uzh.ch.
- Dennler M Department of Clinical Diagnostics and Services, Clinic of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
- Meira C Department of Clinical Diagnostics and Services, Division of Anaesthesiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
- Mosing M Department of Clinical Diagnostics and Services, Division of Anaesthesiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland; College of Veterinary Medicine, School of Veterinary and Life Sciences, Murdoch University, Perth, Australia.
- Richter H Department of Clinical Diagnostics and Services, Clinic of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
- Ringer SK Department of Clinical Diagnostics and Services, Division of Anaesthesiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
- 2019-04-11
Published in:
- Veterinary anaesthesia and analgesia. - 2019
adenosine
anaesthesia
cMRI
cardiovascular
dog
Adenosine
Anesthesia
Animals
Cardiovascular System
Dogs
Dose-Response Relationship, Drug
Female
Heart Rate
Infusions, Intravenous
Longitudinal Studies
Magnetic Resonance Angiography
Male
Propofol
Sevoflurane
Stroke Volume
Vasodilator Agents
English
OBJECTIVE
Adenosine induces vasodilatation. The aim of this study was to investigate cardiovascular effects of two adenosine constant rate infusion (CRI) doses in dogs.
STUDY DESIGN
Experimental, longitudinal repeated measure design.
ANIMALS
Ten healthy purpose-bred Beagle dogs.
METHODS
Each dog was sedated with butorphanol. Anaesthesia was induced with propofol intravenously and maintained with sevoflurane (inspired oxygen fraction = 47-55%). Controlled mechanical ventilation was used to maintain normocapnia. Two doses of adenosine were administered as CRIs to each dog: 140 μg kg-1 minute-1 (A140) followed by 280 μg kg-1 minute-1 (A280). Pulse rate, invasive arterial pressure and stroke volume (by magnetic resonance phase contrast angiography) were measured at baseline, 3 minutes after starting adenosine and 3 and 10 minutes after discontinuing adenosine. Cardiac output, cardiac index and approximated systemic vascular resistances (approximate SVR) were calculated. Additionally, arterial blood gases, co-oximetry, electrolytes, glucose and lactate were measured and oxygen content and delivery calculated. One-way repeated measures analysis of variance (p < 0.05) was used for data analysis.
RESULTS
A140 and A280 resulted in a significant decrease in arterial blood pressure [systolic (p = 0.008), mean (p = 0.003), and diastolic arterial pressure (p = 0.004)] and approximate SVR (p = 0.008) compared with baseline. No significant changes were detected for the other variables. All values returned to baseline within 3 minutes after adenosine discontinuation.
CONCLUSIONS AND CLINICAL RELEVANCE
Adenosine CRI decreases arterial pressure by vasodilatation in healthy dogs. No additional effects were observed with the higher dose. The effects in compromised dogs remain to be investigated.
Adenosine induces vasodilatation. The aim of this study was to investigate cardiovascular effects of two adenosine constant rate infusion (CRI) doses in dogs.
STUDY DESIGN
Experimental, longitudinal repeated measure design.
ANIMALS
Ten healthy purpose-bred Beagle dogs.
METHODS
Each dog was sedated with butorphanol. Anaesthesia was induced with propofol intravenously and maintained with sevoflurane (inspired oxygen fraction = 47-55%). Controlled mechanical ventilation was used to maintain normocapnia. Two doses of adenosine were administered as CRIs to each dog: 140 μg kg-1 minute-1 (A140) followed by 280 μg kg-1 minute-1 (A280). Pulse rate, invasive arterial pressure and stroke volume (by magnetic resonance phase contrast angiography) were measured at baseline, 3 minutes after starting adenosine and 3 and 10 minutes after discontinuing adenosine. Cardiac output, cardiac index and approximated systemic vascular resistances (approximate SVR) were calculated. Additionally, arterial blood gases, co-oximetry, electrolytes, glucose and lactate were measured and oxygen content and delivery calculated. One-way repeated measures analysis of variance (p < 0.05) was used for data analysis.
RESULTS
A140 and A280 resulted in a significant decrease in arterial blood pressure [systolic (p = 0.008), mean (p = 0.003), and diastolic arterial pressure (p = 0.004)] and approximate SVR (p = 0.008) compared with baseline. No significant changes were detected for the other variables. All values returned to baseline within 3 minutes after adenosine discontinuation.
CONCLUSIONS AND CLINICAL RELEVANCE
Adenosine CRI decreases arterial pressure by vasodilatation in healthy dogs. No additional effects were observed with the higher dose. The effects in compromised dogs remain to be investigated.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.vaa.2018.12.007
- PMID 30967341
- Persistent URL
- https://sonar.ch/global/documents/47501
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