Journal article
Is there a relationship between genetic factors and the incidence and severity of H1N1 in Kosova?: A preliminary investigation and pointers for further research.
- Dreshaj S University of Prishtina, Faculty of Medicine, Clinic of Infectious Diseases, Prishtina University Clinical Centre, Kosovo. Electronic address: shemsedin.dreshaj@uni-pr.edu.
- Alija AJ University of Prishtina, Department of Biology, Nena Tereze, n.n., Prishtina, Kosova.
- Schlagenhauf P University of Zurich, Centre for Travel Medicine, Epidemiology, Biostatistics and Prevention Institute, Hirschengraben 84, 8032 Switzerland.
- Doda T University of Prishtina, Faculty of Medicine, Clinic of Infectious Diseases, Prishtina University Clinical Centre, Kosovo.
- Geca N University of Prishtina, Faculty of Medicine, Clinic of Infectious Diseases, Prishtina University Clinical Centre, Kosovo.
- Bajraktari I University of Prishtina, Department of Biology, Nena Tereze, n.n., Prishtina, Kosova.
- Bresgen N University of Salzburg, Department of Cell Biology, Hellbrunnerstr. 34, A-5020 Salzburg, Austria.
- Eckl PM University of Salzburg, Department of Cell Biology, Hellbrunnerstr. 34, A-5020 Salzburg, Austria.
- 2017-03-18
Published in:
- Travel medicine and infectious disease. - 2017
H1N1
Kosovo
Patients
Phenotype
Susceptibility
Adult
Female
Genetic Predisposition to Disease
Humans
Incidence
Influenza A Virus, H1N1 Subtype
Influenza, Human
Kosovo
Male
Phenotype
Retrospective Studies
Young Adult
English
BACKGROUND
Host genetic factors may impact susceptibility to infection. A small number of studies have investigated the association between factors such as ABO blood groups and selected phenotypes on the incidence and severity of H1N1 infections with inconclusive results.
METHODS
Using data from the Clinic of Infectious Diseases - University Clinical Centre Prishtina and based on the examination of 125 patients hospitalized with H1N1 in the period 2009-2014, the frequency of blood groups from ABO and Rhesus (Rh) systems as phenotypical markers were evaluated. In addition, other phenotypes such as ear lobe free/ear lobe attached, normal chin/cleft chin, tongue roller/non roller, hand clasping right thumb over/hand clasping left thumb over, right-handed/left-handed, dark eyes/light eyes were also analyzed. The data obtained from the 125 hospitalized patients were compared with the data from the Kosovar population (n = 2000) as a reference group.
RESULTS
A total of 303 patients with H1N1 were hospitalized in the period 2009-2015. Blood group and phenotype data available from 125 hospitalized H1N1 patients showed significant differences in the frequencies of the blood groups from Rh system as well as in two (out of six) phenotypes of the selected morphological traits compared to reference groups.
CONCLUSIONS
The findings from this preliminary study indicate that these Rh system and phenotype differences may be linked to H1N1 susceptibility and may guide identification of risk groups and populations.
Host genetic factors may impact susceptibility to infection. A small number of studies have investigated the association between factors such as ABO blood groups and selected phenotypes on the incidence and severity of H1N1 infections with inconclusive results.
METHODS
Using data from the Clinic of Infectious Diseases - University Clinical Centre Prishtina and based on the examination of 125 patients hospitalized with H1N1 in the period 2009-2014, the frequency of blood groups from ABO and Rhesus (Rh) systems as phenotypical markers were evaluated. In addition, other phenotypes such as ear lobe free/ear lobe attached, normal chin/cleft chin, tongue roller/non roller, hand clasping right thumb over/hand clasping left thumb over, right-handed/left-handed, dark eyes/light eyes were also analyzed. The data obtained from the 125 hospitalized patients were compared with the data from the Kosovar population (n = 2000) as a reference group.
RESULTS
A total of 303 patients with H1N1 were hospitalized in the period 2009-2015. Blood group and phenotype data available from 125 hospitalized H1N1 patients showed significant differences in the frequencies of the blood groups from Rh system as well as in two (out of six) phenotypes of the selected morphological traits compared to reference groups.
CONCLUSIONS
The findings from this preliminary study indicate that these Rh system and phenotype differences may be linked to H1N1 susceptibility and may guide identification of risk groups and populations.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.tmaid.2017.03.005
- PMID 28302522
- Persistent URL
- https://sonar.ch/global/documents/47505
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