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A causal account of the brain network computations underlying strategic social behavior.
Journal article

A causal account of the brain network computations underlying strategic social behavior.

  • Hill CA Laboratory for Social and Neural Systems Research (SNS-Lab), Department of Economics, University of Zurich, Zurich, Switzerland.
  • Suzuki S Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Miyagi, Japan.
  • Polania R Laboratory for Social and Neural Systems Research (SNS-Lab), Department of Economics, University of Zurich, Zurich, Switzerland.
  • Moisa M Laboratory for Social and Neural Systems Research (SNS-Lab), Department of Economics, University of Zurich, Zurich, Switzerland.
  • O'Doherty JP Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena, California, USA.
  • Ruff CC Laboratory for Social and Neural Systems Research (SNS-Lab), Department of Economics, University of Zurich, Zurich, Switzerland.
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  • 2017-07-11
Published in:
  • Nature neuroscience. - 2017
Adolescent
Adult
Brain
Brain Mapping
Decision Making
Female
Humans
Magnetic Resonance Imaging
Male
Social Behavior
Theory of Mind
Transcranial Magnetic Stimulation
Young Adult
English During competitive interactions, humans have to estimate the impact of their own actions on their opponent's strategy. Here we provide evidence that neural computations in the right temporoparietal junction (rTPJ) and interconnected structures are causally involved in this process. By combining inhibitory continuous theta-burst transcranial magnetic stimulation with model-based functional MRI, we show that disrupting neural excitability in the rTPJ reduces behavioral and neural indices of mentalizing-related computations, as well as functional connectivity of the rTPJ with ventral and dorsal parts of the medial prefrontal cortex. These results provide a causal demonstration that neural computations instantiated in the rTPJ are neurobiological prerequisites for the ability to integrate opponent beliefs into strategic choice, through system-level interaction within the valuation and mentalizing networks.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/47616
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