Journal article
Human bocaviruses and paediatric infections.
- Christensen A Department of Medical Microbiology, St Olavs Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: andreas.christensen@stolav.no.
- Kesti O Department of Paediatrics, Turku University Hospital and University of Turku, Turku, Finland.
- Elenius V Department of Paediatrics, Turku University Hospital and University of Turku, Turku, Finland.
- Eskola AL Department of Education, University of Turku, Turku, Finland.
- Døllner H Department of Pediatrics, St Olavs Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
- Altunbulakli C Swiss Institute of Allergy and Asthma Research, University of Zürich and Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.
- Akdis CA Swiss Institute of Allergy and Asthma Research, University of Zürich and Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.
- Söderlund-Venermo M Department of Virology, University of Helsinki, Helsinki, Finland.
- Jartti T Department of Paediatrics, Turku University Hospital and University of Turku, Turku, Finland.
- 2019-04-06
Published in:
- The Lancet. Child & adolescent health. - 2019
English
Human bocavirus 1 (HBoV1), belonging to the Parvoviridae family, was discovered in 2005, in nasopharyngeal samples from children with respiratory tract infections. Three additional bocaviruses, HBoV2-4, were discovered in 2009-10. These viruses have mainly been found in faecal samples and their role in human diseases is still uncertain. HBoV1 causes a wide spectrum of respiratory diseases in children, including common cold, acute otitis media, pneumonia, bronchiolitis, and asthma exacerbations. HBoV1 DNA can persist in airway secretions for months after an acute infection. Consequently, acute HBoV1 infection cannot be diagnosed with standard DNA PCR; quantitative PCR and serology are better diagnostic approaches. Because of their high clinical specificity, diagnostic developments such as HBoV1 mRNA and antigen detection have shown promising results. This Review summarises the knowledge on human bocaviruses, with a special focus on HBoV1.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/S2352-4642(19)30057-4
- PMID 30948251
- Persistent URL
- https://sonar.ch/global/documents/47727
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