The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue.

Brisch R; Saniotis A; Wolf R; Bielau H; Bernstein HG; Steiner J; Bogerts B; Braun K; Braun AK; Jankowski Z; Kumaratilake J; Kumaritlake J; Henneberg M; Gos T

doi:10.3389/fpsyt.2014.00047

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Journal article

The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue.

Brisch R Department of Forensic Medicine, Medical University of Gdańsk , Gdańsk , Poland.
Saniotis A School of Medical Sciences, The University of Adelaide , Adelaide, SA , Australia ; Centre for Evolutionary Medicine, University of Zurich , Zurich , Switzerland.
Wolf R Department of Psychiatry and Psychotherapy, Ruhr University Bochum , Bochum , Germany.
Bielau H Department of Psychiatry, Otto-von-Guericke-University of Magdeburg , Magdeburg , Germany.
Bernstein HG Department of Psychiatry, Otto-von-Guericke-University of Magdeburg , Magdeburg , Germany.
Steiner J Department of Psychiatry, Otto-von-Guericke-University of Magdeburg , Magdeburg , Germany.
Bogerts B Department of Psychiatry, Otto-von-Guericke-University of Magdeburg , Magdeburg , Germany.
Braun K Department of Zoology, Institute of Biology, Otto-von-Guericke-University of Magdeburg , Magdeburg , Germany.
Braun AK Department of Forensic Medicine, Medical University of Gdańsk , Gdańsk , Poland.
Jankowski Z Biological Anthropology and Comparative Anatomy Research Unit, School of Biomedical Sciences, The University of Adelaide , Adelaide, SA , Australia.
Kumaratilake J Biological Anthropology and Comparative Anatomy Research Unit, School of Biomedical Sciences, The University of Adelaide , Adelaide, SA , Australia.
Kumaritlake J Department of Forensic Medicine, Medical University of Gdańsk , Gdańsk , Poland.
Henneberg M
Gos T

2014-06-07

Published in:

Frontiers in psychiatry. - 2014

animal models of schizophrenia

English Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. However, recent research has indicated that glutamate, GABA, acetylcholine, and serotonin alterations are also involved in the pathology of schizophrenia. This review provides an in-depth analysis of dopamine in animal models of schizophrenia and also focuses on dopamine and cognition. Furthermore, this review provides not only an overview of dopamine receptors and the antipsychotic effects of treatments targeting them but also an outline of dopamine and its interaction with other neurochemical models of schizophrenia. The roles of dopamine in the evolution of the human brain and human mental abilities, which are affected in schizophrenia patients, are also discussed.

Language

English

Open access status

gold

Identifiers

DOI 10.3389/fpsyt.2014.00047
PMID 24904434

Persistent URL

https://sonar.ch/global/documents/47823

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