Journal article
Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.
- Matsumoto T Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
- Rauskolb S
- Polack M
- Klose J
- Kolbeck R
- Korte M
- Barde YA
- 2008-01-22
Published in:
- Nature neuroscience. - 2008
Animals
Brain-Derived Neurotrophic Factor
COS Cells
Chlorocebus aethiops
Dose-Response Relationship, Radiation
Electric Stimulation
Enzyme-Linked Immunosorbent Assay
Hippocampus
Immunoprecipitation
Long-Term Potentiation
Methionine
Mice
Mice, Knockout
Neurons
Patch-Clamp Techniques
Protein Precursors
Synaptic Transmission
Transfection
Tritium
English
Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1038/nn2038
- PMID 18204444
- Persistent URL
- https://sonar.ch/global/documents/4802
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