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Active Cholesterol Efflux in the Retina and Retinal Pigment Epithelium.
Journal article

Active Cholesterol Efflux in the Retina and Retinal Pigment Epithelium.

  • Storti F Lab for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland. federica.storti@usz.ch.
  • Grimm C Lab for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland.
  • 2019-12-30
Published in:
  • Advances in experimental medicine and biology. - 2019
ABCA1
ABCG1
Active cholesterol efflux
Cholesterol
HDL
LXR
Lipid transport
Lipids
RPE
Reverse cholesterol transport
ATP Binding Cassette Transporter 1
ATP Binding Cassette Transporter, Subfamily G, Member 1
Animals
Biological Transport
Cholesterol
Macular Degeneration
Mice
Mice, Knockout
Retinal Pigment Epithelium
English The importance of cholesterol as a structural component of photoreceptors and the association between impaired cholesterol homeostasis and age-related macular degeneration (AMD) prompted in the last years a deep investigation of its metabolism in the retina. Here, we focus on the export of cholesterol from intracellular membranes to extracellular acceptors, an active mechanism mediated by the ATP-binding cassette transporters A1 and G1 (ABCA1 and G1) also known as "active cholesterol efflux." Expression of genes involved in this pathway was shown for most retinal cells, while functional in vitro assays focused on the retinal pigment epithelium (RPE) due to availability of cell models. Cell-specific knockout (KO) mice were generated in the past years, and their characterization unveils an important role of the ABCA1/G1 pathway in RPE, rods, and retinal inflammatory cells. The actual involvement of cholesterol efflux in the pathogenesis of AMD still needs to be demonstrated and will help in establishing the scientific rationale for targeting the ABCA1/G1 pathway in retinal diseases.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/48115
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