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Rhodium(III)-Catalyzed Cyclopropane C-H/C-C Activation Sequence Provides Diastereoselective Access to α-Alkoxylated γ-Lactams.
Journal article

Rhodium(III)-Catalyzed Cyclopropane C-H/C-C Activation Sequence Provides Diastereoselective Access to α-Alkoxylated γ-Lactams.

  • Audic B Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), SB-ISIC, BCH4305, 1015 Lausanne, Switzerland.
  • Cramer N Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), SB-ISIC, BCH4305, 1015 Lausanne, Switzerland.
  • 2020-07-03
Published in:
  • Organic letters. - 2020
Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry
English A Cp*Rh(III)-catalyzed C-H/C-C bond activation sequence of cyclopropyl hydroxamates has been developed. The three-component process allows trapping of the intermediate rhodacycle with diazomalonates and an alcohol nucleophile to provide access to synthetically valuable α-alkoxylated γ-lactams with trans diastereoselectivity.
Language
  • English
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closed
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https://sonar.ch/global/documents/48868
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