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Transcriptional regulation of tenascin genes.

  • 2015-03-21
Published in:
  • Cell adhesion & migration. - 2015
AKT, v-akt murine thymoma viral oncogene homolog
ALK, anaplastic lymphoma kinase
AP-1, activator protein-1
ATF, activating transcription factor
BMP, bone morphogenetic protein
CBP, CREB binding protein
CREB, cAMP response element-binding protein
CREB-RP, CREB-related protein
CYP21A2, cytochrome P450 family 21 subfamily A polypeptide 2
ChIP, chromatin immunoprecipitation
EBS, Ets binding site
ECM, extracellular matrix
EGF, epidermal growth factor
ERK1/2, extracellular signal-regulated kinase 1/2
ETS, E26 transformation-specific
EWS-ETS, Ewing sarcoma-Ets fusion protein
Evx1, even skipped homeobox 1
FGF, fibroblast growth factor
HBS, homeodomain binding sequence
IL, interleukin
ILK, integrin-linked kinase
JAK, Janus kinase
JNK, c-Jun N-terminal kinase
MHCIII, major histocompatibility complex class III
MKL1, megakaryoblastic leukemia-1
NFκB, nuclear factor kappa B
NGF, nerve growth factor; NFAT, nuclear factor of activated T-cells
OTX2, orthodenticle homolog 2
PDGF, platelet-derived growth factor
PI3K, phosphatidylinositol 3-kinase
POU3F2, POU domain class 3 transcription factor 2
PRRX1, paired-related homeobox 1
RBPJk, recombining binding protein suppressor of hairless
ROCK, Rho-associated, coiled-coil-containing protein kinase
RhoA, ras homolog gene family member A
SAP, SAF-A/B, Acinus, and PIAS
SCX, scleraxix
SEAP, secreted alkaline phosphatase
SMAD, small body size - mothers against decapentaplegic
SOX4, sex determining region Y-box 4
SRE, serum response element
SRF, serum response factor
STAT, signal transducer and activator of transcription
TGF-β, transforming growth factor-β
TNC, tenascin-C
TNF-α, tumor necrosis factor-α
TNR, tenascin-R
TNW, tenascin-W
TNX, tenascin-X
TSS, transcription start site
UTR, untranslated region
WNT, wingless-related integration site
cancer
cytokine
development
extracellular matrix
gene promoter
gene regulation
glucocorticoid
growth factor
homeobox gene
matricellular
mechanical stress
miR, micro RNA
p38 MAPK, p38 mitogen activated protein kinase
tenascin
transcription factor
Animals
Central Nervous System
Gene Expression Regulation
Humans
Signal Transduction
Tenascin
English Extracellular matrix proteins of the tenascin family resemble each other in their domain structure, and also share functions in modulating cell adhesion and cellular responses to growth factors. Despite these common features, the 4 vertebrate tenascins exhibit vastly different expression patterns. Tenascin-R is specific to the central nervous system. Tenascin-C is an "oncofetal" protein controlled by many stimuli (growth factors, cytokines, mechanical stress), but with restricted occurrence in space and time. In contrast, tenascin-X is a constituitive component of connective tissues, and its level is barely affected by external factors. Finally, the expression of tenascin-W is similar to that of tenascin-C but even more limited. In accordance with their highly regulated expression, the promoters of the tenascin-C and -W genes contain TATA boxes, whereas those of the other 2 tenascins do not. This article summarizes what is currently known about the complex transcriptional regulation of the 4 tenascin genes in development and disease.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/49440
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