T-Cell-Mediated Cross-Protective Immunity.

Khanna N; Stuehler C

doi:10.1007/978-1-4939-7104-6_20

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Journal article

T-Cell-Mediated Cross-Protective Immunity.

Khanna N Division of Infectious Diseases and Hospital Epidemiology, Departments of Biomedicine and Clinical Research, University Hospital of Basel, Basel, Switzerland.
Stuehler C Infection Biology Laboratory, Department of Biomedicine, University and University Hospital of Basel, Hebelstrasse 20, 4031, Basel, Switzerland. claudia.stuehler@unibas.ch.

2017-06-07

Published in:

Methods in molecular biology (Clifton, N.J.). - 2017

Enzyme-Linked Immunospot Assay

English Human invasive fungal infections are caused by different mold and yeast species. Hence, cross-reactive T cells that recognize conserved epitopes of various fungal pathogens are of special interest for vaccination protocols or adoptive T cell transfer. Here, we describe an ELISpot-based method to test cross-reactivity of T cell lines or clones to different molds and yeasts.

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