Journal article
Vitamin C as an Anticancer Agent: Regulation of Signaling Pathways.
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Butt G
Department of Botany, Government College University, Lahore, Pakistan.
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Farooqi AA
Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.
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Adylova A
Department of Postgraduate Education and Research, Kazakhstan Medical University KSPH, Almaty, Kazakhstan.
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Attar R
Department of Obstetrics and Gynecology, Yeditepe University, Istanbul, Turkey.
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Yilmaz S
Department of Anatomy, Yozgat Bozok University, Faculty of Medicine, Yozgat, Turkey.
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Konysbayevna KK
Ministry of Health of the Republic of Kazakhstan, Zhibek zholy 5, Almaty, Kazakhstan.
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Sabitaliyevich UY
Department of Postgraduate Education and Research, Kazakhstan Medical University KSPH, Almaty, Kazakhstan.
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Gasparri ML
Department of Obstetrics and Gynecology, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Universita' della Svizzera Italiana, Lugano, Switzerland.
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Xu B
Food Science and Technology Program, BNU-HKBU United International College, Zhuhai 519087, China.
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Published in:
- Current topics in medicinal chemistry. - 2020
English
Treatment options for effective treatment of cancer with minimum off-target effects and maximum clinical outcomes have remained overarching goals in the clinical oncology. Vitamin C has remained in the shadows of controversy since the past few decades; burgeoning evidence has started to shed light on wide-ranging anticancer effects exerted by Vitamin C to induce apoptosis in drug-resistant cancer cells, inhibit uncontrolled proliferation of the cancer cells and metastatic spread. Landmark achievements in molecular oncology have ushered in a new era, and researchers have focused on the identification of oncogenic pathways regulated by Vitamin C in different cancers. However, there are visible knowledge gaps in our understanding related to the ability of Vitamin C to modulate a myriad of transduction cascades. There are scattered pieces of scientific evidence about promising potential of Vitamin C to regulate JAK-STAT, TGF/SMAD, TRAIL and microRNAs in different cancers. However, published data is insufficient and needs to be investigated comprehensively to enable basic and clinical researchers to reap full benefits and promote result-oriented transition of Vitamin C into various phases of clinical trials. In this review, we will emphasize on available evidence related to the regulation of oncogenic cell signaling pathways by Vitamin C in different cancers. We will also highlight the conceptual gaps, which need detailed and cutting-edge research.
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Language
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Open access status
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closed
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Persistent URL
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https://sonar.ch/global/documents/51587
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