Journal article
Bayesian class discovery in microarray datasets.
- 2004-05-11
Published in:
- IEEE transactions on bio-medical engineering. - 2004
Algorithms
Bayes Theorem
Cluster Analysis
Databases, Nucleic Acid
Gene Expression Profiling
Genetic Testing
Humans
Leukemia
Models, Genetic
Models, Statistical
Oligonucleotide Array Sequence Analysis
Pattern Recognition, Automated
Reproducibility of Results
Sensitivity and Specificity
Sequence Alignment
Sequence Analysis, DNA
English
A novel approach to class discovery in gene expression datasets is presented. In the context of clinical diagnosis, the central goal of class discovery algorithms is to simultaneously find putative (sub-)types of diseases and to identify informative subsets of genes with disease-type specific expression profile. Contrary to many other approaches in the literature, the method presented implements a wrapper strategy for feature selection, in the sense that the features are directly selected by optimizing the discriminative power of the used partitioning algorithm. The usual combinatorial problems associated with wrapper approaches are overcome by a Bayesian inference mechanism. On the technical side, we present an efficient optimization algorithm with guaranteed local convergence property. The only free parameter of the optimization method is selected by a resampling-based stability analysis. Experiments with Leukemia and Lymphoma datasets demonstrate that our method is able to correctly infer partitions and corresponding subsets of genes which both are relevant in a biological sense. Moreover, the frequently observed problem of ambiguities caused by different but equally high-scoring partitions is successfully overcome by the model selection method proposed.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1109/TBME.2004.824139
- PMID 15132496
- Persistent URL
- https://sonar.ch/global/documents/52607
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