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Self-Assembled Nanomicelles as MRI Blood-Pool Contrast Agent.
Journal article

Self-Assembled Nanomicelles as MRI Blood-Pool Contrast Agent.

  • Babič A Pharmaceutical Technology, School of Pharmacy Geneva-Lausanne, University of Geneva, Rue Michel Servet 1, 1211, Geneva, Switzerland.
  • Vorobiev V Pharmaceutical Technology, School of Pharmacy Geneva-Lausanne, University of Geneva, Rue Michel Servet 1, 1211, Geneva, Switzerland.
  • Xayaphoummine C Pharmaceutical Technology, School of Pharmacy Geneva-Lausanne, University of Geneva, Rue Michel Servet 1, 1211, Geneva, Switzerland.
  • Lapicorey G Institut of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne, Route Cantonale, 1015, Lausanne, Switzerland.
  • Chauvin AS Institut of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne, Route Cantonale, 1015, Lausanne, Switzerland.
  • Helm L Institut of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne, Route Cantonale, 1015, Lausanne, Switzerland.
  • Allémann E Pharmaceutical Technology, School of Pharmacy Geneva-Lausanne, University of Geneva, Rue Michel Servet 1, 1211, Geneva, Switzerland.
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  • 2017-11-10
Published in:
  • Chemistry (Weinheim an der Bergstrasse, Germany). - 2018
contrast agent
gadolinium
magnetic resonance imaging
nanomicelles
self-assembly
Animals
Blood Vessels
Cell Line, Tumor
Cell Survival
Contrast Media
Coordination Complexes
Gadolinium
Humans
Hydrophobic and Hydrophilic Interactions
Magnetic Resonance Imaging
Male
Mice, Inbred C57BL
Micelles
Nanoparticles
Particle Size
Phantoms, Imaging
Surface Properties
Tissue Distribution
Tyrosine
English Gadolinium-loaded nanomicelles show promise as future magnetic resonance imaging (MRI) contrast agents (CAs). Their increased size and high gadolinium (Gd) loading gives them an edge in proton relaxivity over smaller molecular Gd-complexes. Their size and stealth properties are fundamental for their long blood residence time, opening the possibility for use as blood-pool contrast agents. Using l-tyrosine as a three-functional scaffold we synthesized a nanostructure building block 8. The double C18 aliphatic chain on one side, Gd-1,4,7,10-tetraazacyclododecane-1-4-7-triacetic acid (Gd-DO3A) with access to bulk water in the center and 2 kDa PEG on the hydrophilic side gave the amphiphilic properties required for the core-shell nanomicellar architecture. The self-assembly into Gd-loaded monodispersed 10-20 nm nanomicelles occurred spontaneously in water. These nanomicelles (Tyr-MRI) display very high relaxivity at 29 mm-1  s-1 at low field strength and low cytotoxicity. Good contrast enhancement of the blood vessels and the heart together with prolonged circulation time in vivo, makes Tyr-MRI an excellent candidate for a new supramolecular blood-pool MRI CA.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/52956
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