Recent advances in iridium-catalyzed asymmetric hydrogenation: new catalysts, substrates and applications in total synthesis.
- Ganić A Department of Chemistry, University of Basel, Basel, Switzerland. adnan.ganic@unibas.ch
- Rageot D
- Tröndlin L
- Pfaltz A
- 2012-05-23
Published in:
- Chimia. - 2012
English
Iridium-catalyzed asymmetric hydrogenation has emerged as a highly efficient method for the synthesis of enantiomerically pure compounds. This account summarizes our recent efforts in this field. We have developed a new type of P,O-ligand that was successfully applied to the asymmetric hydrogenation of α,β-unsaturated carbonyl compounds. Furthermore we have demonstrated the potential of known iridium catalysts in the hydrogenation of α,β-unsaturated boronic esters. And finally we could demonstrate the utility of iridium-catalyzed asymmetric hydrogenation in the formal synthesis of the natural product Platensimycin.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.2533/chimia.2012.187
- PMID 22613146
- Persistent URL
- https://sonar.ch/global/documents/52966
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