Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative.
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Docherty AR
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT.
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Fonseca-Pedrero E
Department of Psychiatry, Universidad de La Rioja, Oviedo, Spain.
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Debbané M
Research Department of Clinical, Educational, and Health Psychology, University College London, London, UK.
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Chan RCK
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
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Linscott RJ
Department of Psychology, University of Otago, Dunedin, New Zealand.
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Jonas KG
Department of Psychiatry, Stony Brook School of Medicine, Stony Brook, NY.
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Cicero DC
Department of Psychology, University of Hawaii at Manoa, Honolulu, HI.
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Green MJ
School of Psychiatry, University of New South Wales, Sydney, Australia.
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Simms LJ
Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY.
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Mason O
Department of Psychology, University of Surrey, Guildford, UK.
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Watson D
Department of Psychology, University of Notre Dame, Notre Dame, IN.
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Ettinger U
Department of Psychology, University of Bonn, Bonn, Germany.
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Waszczuk M
Department of Psychiatry, Stony Brook School of Medicine, Stony Brook, NY.
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Rapp A
Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
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Grant P
Department of Psychology, Justus-Liebig-University Giessen, Giessen, Germany.
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Kotov R
Department of Psychiatry, Stony Brook School of Medicine, Stony Brook, NY.
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DeYoung CG
Department of Psychology, University of Minnesota, Minneapolis, MN.
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Ruggero CJ
Department of Psychology, University of North Texas, Denton, TX.
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Eaton NR
Department of Psychology, Stony Brook University, Stony Brook, NY.
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Krueger RF
Department of Psychology, University of Minnesota, Minneapolis, MN.
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Patrick C
Department of Psychology, Florida State University, Tallahassee, FL.
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Hopwood C
Department of Psychology, University of California-Davis, Davis, CA.
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O'Neill FA
Centre for Public Health, Institute of Clinical Sciences, Queen's University Belfast, Belfast, UK.
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Zald DH
Department of Psychology, Vanderbilt University, Nashville, TN.
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Conway CC
Department of Psychology, College of William & Mary, Williamsburg, VA.
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Adkins DE
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT.
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Waldman ID
Department of Psychology, Emory University, Atlanta, GA.
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van Os J
Department of Psychiatry and Psychology, Maastricht University Medical Centre, Maastricht, The Netherlands.
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Sullivan PF
Department of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC.
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Anderson JS
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT.
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Shabalin AA
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT.
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Sponheim SR
Department of Psychology, University of Minnesota, Minneapolis, MN.
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Taylor SF
Department of Psychiatry, University of Michigan, Ann Arbor, MI.
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Grazioplene RG
Department of Psychology, Yale University, New Haven, CT.
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Bacanu SA
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA.
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Bigdeli TB
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA.
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Haenschel C
Department of Psychology, City University, London, UK.
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Malaspina D
Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY.
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Gooding DC
Department of Psychology, University of Wisconsin-Madison, Madison, WI.
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Nicodemus K
Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
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Schultze-Lutter F
Department of Psychiatry and Psychotherapy, Heinrich-Heine University, Dusseldorf, Germany.
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Barrantes-Vidal N
Department of Clinical Psychology, Universitat Autònoma de Barcelona, Barcelona, Spain.
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Mohr C
Institute of Psychology, University of Lausanne, Lausanne, Switzerland.
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Carpenter WT
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD.
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Cohen AS
Department of Psychology, Louisiana State University, Baton Rouge, LA.
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Published in:
- Schizophrenia bulletin. - 2018
English
The latent structure of schizotypy and psychosis-spectrum symptoms remains poorly understood. Furthermore, molecular genetic substrates are poorly defined, largely due to the substantial resources required to collect rich phenotypic data across diverse populations. Sample sizes of phenotypic studies are often insufficient for advanced structural equation modeling approaches. In the last 50 years, efforts in both psychiatry and psychological science have moved toward (1) a dimensional model of psychopathology (eg, the current Hierarchical Taxonomy of Psychopathology [HiTOP] initiative), (2) an integration of methods and measures across traits and units of analysis (eg, the RDoC initiative), and (3) powerful, impactful study designs maximizing sample size to detect subtle genomic variation relating to complex traits (the Psychiatric Genomics Consortium [PGC]). These movements are important to the future study of the psychosis spectrum, and to resolving heterogeneity with respect to instrument and population. The International Consortium of Schizotypy Research is composed of over 40 laboratories in 12 countries, and to date, members have compiled a body of schizotypy- and psychosis-related phenotype data from more than 30000 individuals. It has become apparent that compiling data into a protected, relational database and crowdsourcing analytic and data science expertise will result in significant enhancement of current research on the structure and biological substrates of the psychosis spectrum. The authors present a data-sharing infrastructure similar to that of the PGC, and a resource-sharing infrastructure similar to that of HiTOP. This report details the rationale and benefits of the phenotypic data collective and presents an open invitation for participation.
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Language
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Open access status
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bronze
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Identifiers
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Persistent URL
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https://sonar.ch/global/documents/53067
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