Back
Photochemical protection of amines with Cbz and Fmoc groups.
Journal article

Photochemical protection of amines with Cbz and Fmoc groups.

  • Helgen C Department of Chemistry, University of Geneva, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland.
  • Bochet CG
  • 2003-03-15
Published in:
  • The Journal of organic chemistry. - 2003
English The photochemical conversion of amines into carbamates was achieved using N-Cbz-, N-Fmoc-, and N-Boc-5,7-dinitroindolines. This reaction allows the protection of amines in neutral medium. Primary and unhindered secondary amines were protected to yield their benzyloxycarbonyl- and 9-fluorenylmethoxycarbonyl derivatives efficiently, whereas bulky amines or anilines gave low yields or no product. On the other hand, the formation of N-Boc compounds, although possible, proceeded only with low yields.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/5320
Statistics
Document views: 6 File downloads: