Journal article

Greater male than female variability in regional brain structure across the lifespan.

  • Wierenga LM Institute of Psychology, Leiden University, Leiden, The Netherlands.
  • Doucet GE Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Dima D Department of Psychology, School of Arts and Social Sciences, City, University of London, London, UK.
  • Agartz I Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Aghajani M Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
  • Akudjedu TN Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
  • Albajes-Eizagirre A FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
  • Alnaes D Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Alpert KI Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Andreassen OA Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Anticevic A Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
  • Asherson P Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Banaschewski T Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
  • Bargallo N Imaging Diagnostic Center, Hospital Clínic, Barcelona, Spain.
  • Baumeister S Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
  • Baur-Streubel R Department for Clinical Psychology, Würzburg University, Margetshöchheim, Germany.
  • Bertolino A Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
  • Bonvino A Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
  • Boomsma DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
  • Borgwardt S Department of Psychiatry, University of Basel, Basel, Switzerland.
  • Bourque J Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • den Braber A Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
  • Brandeis D Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
  • Breier A Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Brodaty H Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
  • Brouwer RM Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
  • Buitelaar JK Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands.
  • Busatto GF Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
  • Calhoun VD Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Atlanta, Georgia, USA.
  • Canales-Rodríguez EJ FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
  • Cannon DM Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
  • Caseras X MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
  • Castellanos FX Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, New York, USA.
  • Chaim-Avancini TM Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
  • Ching CR Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Clark VP Psychology Clinical Neuroscience Center, Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA.
  • Conrod PJ CHU Sainte-Justine Research Center, Montreal, Quebec, Canada.
  • Conzelmann A Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Tübingen, Germany.
  • Crivello F Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, Bordeaux, France.
  • Davey CG Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia.
  • Dickie EW Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada.
  • Ehrlich S Division of Psychological & Social Medicine and Developmental Neurosciences; Technische Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus, Dresden, Germany.
  • Van't Ent D Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
  • Fisher SE Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
  • Fouche JP Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa.
  • Franke B Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
  • Fuentes-Claramonte P FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
  • de Geus EJ Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
  • Di Giorgio A IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
  • Glahn DC Tommy Fuss Center for Neuropsychiatric Disease Research, Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Gotlib IH Department of Psychology, Stanford University, Stanford, California, USA.
  • Grabe HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
  • Gruber O Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
  • Gruner P Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
  • Gur RE Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Gur RC Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Gurholt TP Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • de Haan L Department of Early Psychosis, Amsterdam UMC, Amsterdam, The Netherlands.
  • Haatveit B Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Harrison BJ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Australia.
  • Hartman CA Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Hatton SN Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
  • Heslenfeld DJ Departments of Experimental and Clinical Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • van den Heuvel OA Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
  • Hickie IB Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
  • Hoekstra PJ Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Hohmann S Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
  • Holmes AJ Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
  • Hoogman M Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
  • Hosten N Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
  • Howells FM Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa.
  • Hulshoff Pol HE Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
  • Huyser C De Bascule, Academic center child and adolescent psychiatry, Duivendrecht, The Netherlands.
  • Jahanshad N Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • James AC Department of Psychiatry, Warneford Hospital, Oxford, UK.
  • Jiang J Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
  • Jönsson EG Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Joska JA Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
  • Kalnin AJ Department of Radiology, The Ohio State University College of Medicine, Columbus, Ohio, USA.
  • Klein M Department of Early Psychosis, Amsterdam UMC, Amsterdam, The Netherlands.
  • Koenders L Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Kolskår KK Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
  • Krämer B Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Kuntsi J Sunshine Coast Mind and Neuroscience Thompson Institute, Birtinya, Queensland, Australia.
  • Lagopoulos J Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
  • Lazaro L Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia.
  • Lebedeva IS Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Lee PH SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, Western Cape, South Africa.
  • Lochner C Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.
  • Machielsen MW Institut des maladies neurodégénératives, Université de Bordeaux, Bordeaux, France.
  • Maingault S Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Martin NG Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain.
  • Martínez-Zalacaín I Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
  • Mataix-Cols D University of Bordeaux, Bordeaux, France.
  • Mazoyer B Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • McDonald BC Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
  • McDonald C Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
  • McIntosh AM Herston Imaging Research Facility and School of Clinical Sciences, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
  • McMahon KL Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
  • McPhilemy G Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • van der Meer D Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
  • Menchón JM Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands.
  • Naaijen J Department of Radiation Sciences, Umeå University, Umeå, Sweden.
  • Nyberg L Emma Children's Hospital, Amsterdam UMC University of Amsterdam and Vrije Universiteit Amsterdam, Emma Neuroscience Group, Department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands.
  • Oosterlaan J Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Paloyelis Y Department of Psychology, University of Würzburg, Würzburg, Germany.
  • Pauli P Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
  • Pergola G FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
  • Pomarol-Clotet E Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
  • Portella MJ Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
  • Radua J Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfur am Maint, Germany.
  • Reif A Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Richard G Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.
  • Roffman JL Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
  • Rosa PG Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA.
  • Sacchet MD Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
  • Sachdev PS FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
  • Salvador R FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
  • Sarró S Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Satterthwaite TD Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Saykin AJ Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
  • Serpa MH West Region, Institute of Mental Health, Singapore, Singapore.
  • Sim K Department of Neuroimaging, Institute of Psychiatry, Psychology and Neurology, King's College London, London, UK.
  • Simmons A Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Smoller JW Department of Biomedical Sciences of Cells and Systems, Rijksuniversiteit Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Sommer IE Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
  • Soriano-Mas C SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, Western Cape, South Africa.
  • Stein DJ Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Strike LT Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Szeszko PR Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
  • Temmingh HS Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Thomopoulos SI Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia.
  • Tomyshev AS Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
  • Trollor JN Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
  • Uhlmann A Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Veer IM Department of Psychiatry & Amsterdam Neuroscience, Amsterdam UMC, location VUMC, Amsterdam, The Netherlands.
  • Veltman DJ Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada.
  • Voineskos A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Völzke H Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Walter H Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Wang L Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Wang Y Institute for Experimental Epileptology and Cognition Research, University Hospital Bonn, Bonn, Germany.
  • Weber B Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
  • Wen W Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • West JD Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Westlye LT Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
  • Whalley HC Department of Neuroimaging, King's College London, London, UK.
  • Williams SC Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
  • Wittfeld K Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Wolf DH Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Wright MJ Department of Child and Adolescent Psychiatry, NYU Child Study Center, Hassenfeld Children's Hospital at NYU Langone, New York, New York,, USA.
  • Yoncheva YN Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
  • Zanetti MV Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
  • Ziegler GC Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
  • de Zubicaray GI Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Thompson PM Institute of Psychology, Leiden University, Leiden, The Netherlands.
  • Crone EA Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Frangou S Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Tamnes CK
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  • 2020-10-12
Published in:
  • Human brain mapping. - 2020
English For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
Language
  • English
Open access status
gold
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https://sonar.ch/global/documents/54474
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