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Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria.

  • Nordmann P Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science and Medicine, University of Fribourg, Switzerland.
  • Poirel L Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science and Medicine, University of Fribourg, Switzerland.
  • 2019-11-15
Published in:
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. - 2019
Acinetobacter baumannii
Pseudomonas aeruginosa
carbapenem-resistant Enterobacteriaceae
carbapenemases
gram-negative bacteria
Carbapenems
Drug Resistance, Bacterial
Global Health
Gram-Negative Bacteria
Gram-Negative Bacterial Infections
Humans
English Carbapenem resistance in gram-negative bacteria has caused a global epidemic that continues to grow. Although carbapenemase-producing Enterobacteriaceae have received the most attention because resistance was first reported in these pathogens in the early 1990s, there is increased awareness of the impact of carbapenem-resistant nonfermenting gram-negative bacteria, such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. Moreover, evaluating the problem of carbapenem resistance requires the consideration of both carbapenemase-producing bacteria as well as bacteria with other carbapenem resistance mechanisms. Advances in rapid diagnostic tests to improve the detection of carbapenem resistance and the use of large, population-based datasets to capture a greater proportion of carbapenem-resistant organisms can help us gain a better understanding of this urgent threat and enable physicians to select the most appropriate antibiotics.
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  • English
Open access status
hybrid
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https://sonar.ch/global/documents/54767
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