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Congenital clubfoot in Europe: A population-based study.

  • Wang H Department of PharmacoTherapy, Epidemiology and Economics (PTEE) / Division: Groninger Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, Belfast, UK.
  • Barisic I Department of Medical Genetics and Reproductive Health, Children's Hospital Zagreb, Medical School University of Zagreb, Zagreb, Croatia.
  • Loane M Institute of Nursing & Health Research, Ulster University, Northern Ireland.
  • Addor MC Department of Woman-Mother-Child, University Hospital Center CHUV, Lausanne, Switzerland.
  • Bailey LM Congenital Anomaly Register and Information Service for Wales, Public Health UK NHS Trust, Swansea, Wales, UK.
  • Gatt M Directorate for Health Information and Research, Tal-Pietà, Malta.
  • Klungsoyr K Division of Mental and Physical Health, Norwegian Institute of Public Health and Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
  • Mokoroa O Malta Congenital Anomalies Register, Directorate for Health Information and Research, G'Mangia, Malta.
  • Nelen V Province of Antwerp Department of Environment, Provincial Institute of Hygiene, Antwerp, Belgium.
  • Neville AJ IMER Registry, Center for Clinical and Epidemiological Research, University of Ferrara and Azienda Ospedaliero Universitario di Ferrara, Ferrara, Italy.
  • O'Mahony M Department of Public Health, Health Service Executive - South, Ireland.
  • Pierini A Tuscany Registry of Congenital Defects, Institute of Clinical Physiology-National Research Council/Fondazione Toscana "Gabriele Monasterio", Pisa, Italy.
  • Rissmann A Malformation Monitoring Centre Saxony-Anhalt, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
  • Verellen-Dumoulin C Center for Human Genetics, Institut de Pathologie et de Génétique, Charleroi, Belgium.
  • de Walle HEK Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
  • Wiesel A Department of Pediatrics, Birth Registry Mainz Model, University Medical Center of Mainz, Mainz, Germany.
  • Wisniewska K Department of Preventive Medicine, Epidemiology Unit, Poznan University of Medical Sciences, Poznan, Poland.
  • de Jong-van den Berg LTW Department of PharmacoTherapy, Epidemiology and Economics (PTEE) / Division: Groninger Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, Belfast, UK.
  • Dolk H Institute of Nursing & Health Research, Ulster University, Northern Ireland.
  • Khoshnood B INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), DHU Risks in Pregnancy, Paris Descartes University, Paris, France.
  • Garne E Paediatric Department, Hospital Lillebaelt Kolding, Kolding, Denmark.
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  • 2019-02-12
Published in:
  • American journal of medical genetics. Part A. - 2019
associated anomalies
congenital lubfoot
prenatal diagnosis
prevalence
trend
Chromosome Aberrations
Clubfoot
Congenital Abnormalities
Europe
Female
Fetal Death
Gestational Age
Humans
Infant
Infant, Newborn
Male
Pregnancy
Prenatal Diagnosis
Prevalence
Registries
Stillbirth
English We aimed to assess prevalence, birth outcome, associated anomalies and prenatal diagnosis of congenital clubfoot in Europe using data from the EUROCAT network, and to validate the recording of congenital clubfoot as a major congenital anomaly by EUROCAT registries. Cases of congenital clubfoot were included from 18 EUROCAT registries covering more than 4.8 million births in 1995-2011. Cases without chromosomal anomalies born during 2005-2009, were randomly selected for validation using a questionnaire on diagnostic details and treatment. There was 5,458 congenital clubfoot cases of which 5,056 (93%) were liveborn infants. Total prevalence of congenital clubfoot was 1.13 per 1,000 births (95% CI 1.10-1.16). Prevalence of congenital clubfoot without chromosomal anomaly was 1.08 per 1,000 births (95% CI 1.05-1.11) and prevalence of isolated congenital clubfoot was 0.92 per 1,000 births (95% CI 0.90-0.95), both with decreasing trends over time and large variations in prevalence by registry. The majority of cases were isolated congenital clubfoot (82%) and 11% had associated major congenital anomalies. Prenatal detection rate of isolated congenital clubfoot was 22% and increased over time. Among 301 validated congenital clubfoot cases, diagnosis was confirmed for 286 (95%). In conclusion, this large population-based study found a decreasing trend of congenital clubfoot in Europe after 1999-2002, an increasing prenatal detection rate, and a high standard of coding of congenital clubfoot in EUROCAT.
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  • English
Open access status
green
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https://sonar.ch/global/documents/54843
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