Journal article
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis.
- Sun W Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. wenfei-sun@ethz.ch.
- Dong H Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
- Balaz M Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
- Slyper M Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- Drokhlyansky E Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- Colleluori G Department of Experimental and Clinical Medicine, Center of Obesity, Marche Polytechnic University, Ancona, Italy.
- Giordano A Department of Experimental and Clinical Medicine, Center of Obesity, Marche Polytechnic University, Ancona, Italy.
- Kovanicova Z Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia.
- Stefanicka P Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine and University Hospital, Comenius University, Bratislava, Slovakia.
- Balazova L Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
- Ding L Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
- Husted AS The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
- Rudofsky G Department of Endocrinology, Cantonal Hospital Olten, Olten, Switzerland.
- Ukropec J Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia.
- Cinti S Department of Experimental and Clinical Medicine, Center of Obesity, Marche Polytechnic University, Ancona, Italy.
- Schwartz TW The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
- Regev A Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- Wolfrum C Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. christian-wolfrum@ethz.ch.
- 2020-10-29
Published in:
- Nature. - 2020
English
Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite)1. It is an important regulator of systemic metabolism, as shown by the fact that dysfunctional adipose tissue in obesity leads to a variety of secondary metabolic complications2,3. In addition, adipose tissue functions as a signalling hub that regulates systemic metabolism through paracrine and endocrine signals4. Here we use single-nucleus RNA-sequencing (snRNA-seq) analysis in mice and humans to characterize adipocyte heterogeneity. We identify a rare subpopulation of adipocytes in mice that increases in abundance at higher temperatures, and we show that this subpopulation regulates the activity of neighbouring adipocytes through acetate-mediated modulation of their thermogenic capacity. Human adipose tissue contains higher numbers of cells of this subpopulation, which could explain the lower thermogenic activity of human compared to mouse adipose tissue and suggests that targeting this pathway could be used to restore thermogenic activity.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1038/s41586-020-2856-x
- PMID 33116305
- Persistent URL
- https://sonar.ch/global/documents/55033
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