Journal article
The substrate specificity of tocopherol cyclase.
- Stocker A Organisch-chemisches Institut der Universität Zürich, Switzerland.
- Fretz H
- Frick H
- Rüttimann A
- Woggon WD
- 1996-07-01
Published in:
- Bioorganic & medicinal chemistry. - 1996
Chemical Phenomena
Chemistry, Physical
Cyanobacteria
Intramolecular Transferases
Isomerases
Substrate Specificity
English
The substrate specificity of the enzyme tocopherol cyclase from the blue-green algae Anabaena variabilis (Cyanobacteria) was investigated with 11 substrate analogues revealing the significance of three major recognition sites: (i) the OH group at C(1) of the hydroquinone, (ii) the (E) configuration of the double bond, and (iii) the length of the lipophilic side chain. Experiments with two affinity matrices suggest that substrates approach the enzyme's active site with the hydrophobic tail.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/0968-0896(96)00125-3
- PMID 8831985
- Persistent URL
- https://sonar.ch/global/documents/55135
Statistics
Document views: 41
File downloads: