Journal article
Safety and Patient-Reported Outcomes of Atezolizumab Plus Chemotherapy With or Without Bevacizumab Versus Bevacizumab Plus Chemotherapy in Non-Small-Cell Lung Cancer.
-
Reck M
Lung Clinic Grosshansdorf, Airway Research Center North, German Center of Lung Research, Grosshansdorf, Germany.
-
Wehler T
Evangelisches Krankenhaus Hamm gGmbH, Hamm, Germany.
-
Orlandi F
Instituto Nacional del Tórax, Santiago, Chile.
-
Nogami N
National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan.
-
Barone C
Università Cattolica del Sacro Cuore, Rome, Italy.
-
Moro-Sibilot D
Centre Hospitalier Universitaire de Grenoble Alpes, Grenoble, France.
-
Shtivelband M
Ironwood Cancer & Research Center, Chandler, AZ.
-
González Larriba JL
Hospital Clínico San Carlos, Madrid, Spain.
-
Rothenstein J
Durham Regional Cancer Center, Lakeridge Health, Oshawa, Ontario, Canada.
-
Früh M
Cantonal Hospital of St Gallen, St Gallen, Switzerland.
-
Yu W
Genentech, South San Francisco, CA.
-
Deng Y
Genentech, South San Francisco, CA.
-
Coleman S
Genentech, South San Francisco, CA.
-
Shankar G
Genentech, South San Francisco, CA.
-
Patel H
Genentech, South San Francisco, CA.
-
Kelsch C
Genentech, South San Francisco, CA.
-
Lee A
Genentech, South San Francisco, CA.
-
Piault E
Genentech, South San Francisco, CA.
-
Socinski MA
AdventHealth Cancer Institute, Orlando, FL.
Show more…
Published in:
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 2020
English
PURPOSE
Atezolizumab, bevacizumab, carboplatin, and paclitaxel (ABCP) demonstrated survival benefit versus bevacizumab, carboplatin, and paclitaxel (BCP) in chemotherapy-naïve nonsquamous non-small-cell lung cancer (NSCLC). We present safety and patient-reported outcomes (PROs) to provide additional information on the relative impact of adding atezolizumab to chemotherapy with and without bevacizumab in nonsquamous NSCLC.
METHODS
Patients were randomly assigned to receive atezolizumab, carboplatin, and paclitaxel (ACP), ABCP, or BCP. Coprimary end points were overall survival and investigator-assessed progression-free survival. The incidence, nature, and severity of adverse events (AEs) were assessed. PROs, a secondary end point, were evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-Core 30 and EORTC QLQ-Lung Cancer 13.
RESULTS
Overall, 400 (ACP), 393 (ABCP), and 394 (BCP) patients were safety evaluable (ie, intention-to-treat population that received one or more doses of any study treatment). More patients had grade 3/4 treatment-related AEs during the induction versus maintenance phase (ACP, 40.5% v 8.2%; ABCP, 48.6% v 21.2%; BCP, 44.7% v 11.1%). During induction, the incidence of serious AEs (SAEs) was 28.3%, 28.5%, and 26.4% in the ACP, ABCP, and BCP arms, respectively. During maintenance, SAE incidences were 20.0%, 26.3%, and 13.0%, respectively. Completion rates of the PRO questionnaires were > 88% at baseline and remained ≥ 70% throughout most study visits. Across arms, patients on average reported no clinically meaningful worsening of global health status or physical functioning scores through cycle 13. Patients across arms rated common symptoms with chemotherapy and immunotherapy similarly.
CONCLUSION
ABCP seems tolerable and manageable versus ACP and BCP in first-line nonsquamous NSCLC. Treatment tolerability differed between induction and maintenance phases across treatment arms. PROs reflect a minimal treatment burden (eg, health-related quality of life, symptoms) with each regimen.
-
Language
-
-
Open access status
-
hybrid
-
Identifiers
-
-
Persistent URL
-
https://sonar.ch/global/documents/55905
Statistics
Document views: 18
File downloads: