Journal article
Severe transfusion-related acute lung injury.
- Brander L Department of Intensive Care Medicine, University Hospital, Inselspital, 3010 Bern, Switzerland. lukas.brander@insel.ch
- Reil A
- Bux J
- Taleghani BM
- Regli B
- Takala J
- 2005-07-23
Published in:
- Anesthesia and analgesia. - 2005
Acute Disease
Antibody Specificity
Blood Cell Count
Cardiac Surgical Procedures
Granulocytes
Hemodynamics
Humans
Isoantibodies
Lung
Lung Injury
Male
Middle Aged
Plasma
Radiography
Transfusion Reaction
English
UNLABELLED
A 46-yr-old man developed severe hypoxemia, pulmonary infiltrates, and an acute decrease in his leukocyte count shortly after transfusion of fresh-frozen plasma (FFP) during recovery from cardiac surgery. Cardiogenic pulmonary edema was excluded. Granulocyte-reactive and agglutinating alloantibodies were detected in the serum of the fresh-frozen plasma donor. The cross-match with the patient's granulocytes revealed antibodies specific for HLA class I. Transfusion-related acute lung injury (TRALI) is a potentially life-threatening, under-recognized and under-reported complication of transfusion. Conservative transfusion strategies and preclusion of the implicated blood donors with granulocyte-reactive antibodies from future blood donation may prevent TRALI and could save lives.
IMPLICATIONS
Transfusion-related acute lung injury (TRALI) is a potentially life-threatening, probably under-recognized and under-reported complication of transfusing blood products. Conservative transfusion strategies and preclusion of the implicated blood donors with granulocyte-reactive antibodies from future blood donation may prevent TRALI and potentially save lives.
A 46-yr-old man developed severe hypoxemia, pulmonary infiltrates, and an acute decrease in his leukocyte count shortly after transfusion of fresh-frozen plasma (FFP) during recovery from cardiac surgery. Cardiogenic pulmonary edema was excluded. Granulocyte-reactive and agglutinating alloantibodies were detected in the serum of the fresh-frozen plasma donor. The cross-match with the patient's granulocytes revealed antibodies specific for HLA class I. Transfusion-related acute lung injury (TRALI) is a potentially life-threatening, under-recognized and under-reported complication of transfusion. Conservative transfusion strategies and preclusion of the implicated blood donors with granulocyte-reactive antibodies from future blood donation may prevent TRALI and could save lives.
IMPLICATIONS
Transfusion-related acute lung injury (TRALI) is a potentially life-threatening, probably under-recognized and under-reported complication of transfusing blood products. Conservative transfusion strategies and preclusion of the implicated blood donors with granulocyte-reactive antibodies from future blood donation may prevent TRALI and potentially save lives.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1213/01.ANE.0000159375.26910.9C
- PMID 16037167
- Persistent URL
- https://sonar.ch/global/documents/55928
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