Association of adult lung function with accelerated biological aging.

Rezwan FI; Imboden M; Amaral AFS; Wielscher M; Jeong A; Triebner K; Real FG; Jarvelin MR; Jarvis D; Probst-Hensch NM; Holloway JW

doi:10.18632/aging.102639

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Journal article

Association of adult lung function with accelerated biological aging.

Rezwan FI Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Imboden M Chronic Disease Epidemiology Unit, Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Amaral AFS Population Health and Occupational Disease, NHLI, Imperial College London, London, United Kingdom.
Wielscher M Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom.
Jeong A Chronic Disease Epidemiology Unit, Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Triebner K Department of Clinical Science, University of Bergen, Bergen, Norway.
Real FG Department of Clinical Science, University of Bergen, Bergen, Norway.
Jarvelin MR Population Health and Occupational Disease, NHLI, Imperial College London, London, United Kingdom.
Jarvis D Population Health and Occupational Disease, NHLI, Imperial College London, London, United Kingdom.
Probst-Hensch NM Chronic Disease Epidemiology Unit, Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Holloway JW Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

2020-01-12

Published in:

Aging. - 2020

English Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed.AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10-4; Intrinsic Epigenetic AA:P-value=2x10-4) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10-17).This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults.

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