Journal article
Combined Effect of Age and Baseline Alberta Stroke Program Early Computed Tomography Score on Post-Thrombectomy Clinical Outcomes in the MR CLEAN Registry
-
Ospel, Johanna
Neuroradiology, University Hospital Basel, Switzerland (J.O.).
-
Kappelhof, Manon
ORCID
Radiology & Nuclear Medicine (M.K., L.F.M.B., C.B.L.M.M.), Amsterdam UMC, University of Amsterdam, the Netherlands.
-
Groot, Adrien E.
Neurology (A.E.G., N.E.L., J.M.C., Y.B.W.E.M.R.), Amsterdam UMC, University of Amsterdam, the Netherlands.
-
LeCouffe, Natalie E.
Neurology (A.E.G., N.E.L., J.M.C., Y.B.W.E.M.R.), Amsterdam UMC, University of Amsterdam, the Netherlands.
-
Coutinho, Jonathan M.
Neurology (A.E.G., N.E.L., J.M.C., Y.B.W.E.M.R.), Amsterdam UMC, University of Amsterdam, the Netherlands.
-
Yoo, Albert J.
Radiology, Texas Stroke Institute, Dallas (A.J.Y.).
-
Yo, Lonneke S.F.
Radiology, Catharina Hospital, Eindhoven, the Netherlands (L.S.F.Y.).
-
Beenen, Ludo F.M.
ORCID
Radiology & Nuclear Medicine (M.K., L.F.M.B., C.B.L.M.M.), Amsterdam UMC, University of Amsterdam, the Netherlands.
-
van Zwam, Wim H.
Radiology and Nuclear Medicine, Cardiovascular Research Institute Maastricht, School for Mental Health and Sciences, Maastricht University Medical Center, the Netherlands (W.H.v.Z., A.A.P.).
-
van der Lugt, Aad
Radiology and Nuclear Medicine, Erasmus MC – University Medical Center, Rotterdam, the Netherlands (A.v.d.L.).
-
Postma, Alida A.
Radiology and Nuclear Medicine, Cardiovascular Research Institute Maastricht, School for Mental Health and Sciences, Maastricht University Medical Center, the Netherlands (W.H.v.Z., A.A.P.).
-
Roos, Yvo B.W.E.M.
Neurology (A.E.G., N.E.L., J.M.C., Y.B.W.E.M.R.), Amsterdam UMC, University of Amsterdam, the Netherlands.
-
Goyal, Mayank
Diagnostic Imaging (M.G.), University of Calgary, Alberta, Canada.
-
Majoie, Charles B.L.M.
ORCID
Radiology & Nuclear Medicine (M.K., L.F.M.B., C.B.L.M.M.), Amsterdam UMC, University of Amsterdam, the Netherlands.
-
Dippel, Diederik W.J.
-
van Oostenbrugge, Robert J.
-
Boiten, Jelis
-
Albert Vos, Jan
-
Jansen, Ivo G.H.
-
Mulder, Maxim J.H.L.
-
Goldhoorn, Robert- Jan B.
-
Compagne, Kars C.J.
-
Brouwer, Josje
-
den Hartog, Sanne J.
-
Hinsenveld, Wouter H.
-
Roozenbeek, Bob
-
van Es, Adriaan C.G.M.
-
Emmer, Bart J.
-
Schonewille, Wouter J.
-
Wermer, Marieke J.H.
-
van Walderveen, Marianne A.A.
-
Staals, Julie
-
Hofmeijer, Jeannette
-
Martens, Jasper M.
-
Lycklama à Nijeholt, Geert J.
-
de Bruijn, Sebastiaan F.
-
van Dijk, Lukas C.
-
van der Worp, H. Bart
-
Lo, Rob H.
-
van Dijk, Ewoud J.
-
Boogaarts, Hieronymus D.
-
de Vries, J.
-
de Kort, Paul L.M.
-
van Tuijl, Julia
-
Peluso, Jo P.
-
Fransen, Puck
-
van den Berg, Jan S.P.
-
van Hasselt, Boudewijn A.A.M.
-
Aerden, Leo A.M.
-
Dallinga, René J.
-
Uyttenboogaart, Maarten
-
Eschgi, Omid
-
Bokkers, Reinoud P.H.
-
Schreuder, Tobien H.C.M.L.
-
Heijboer, Roel J.J.
-
Keizer, Koos
-
den Hertog, Heleen M.
-
Sturm, Emiel J.C.
-
Brouwers, Paul J.A.M.
-
Sprengers, Marieke E.S.
-
Jenniskens, Sjoerd F.M.
-
van den Berg, René
-
Roosendaal, Stefan D.
-
van der Kallen, Bas F.W.
-
van den Wijngaard, Ido R.
-
Bot, Joost
-
van Doormaal, Pieter-Jan
-
Meijer, Anton
-
Ghariq, Elyas
-
Bokkers, Reinoud P.H.
-
van Proosdij, Marc P.
-
Krietemeijer, G. Menno
-
Peluso, Jo P.
-
Lo, Rob
-
Gerrits, Dick
-
Dinkelaar, Wouter
-
Appelman, Auke P.A.
-
Hammer, Bas
-
Pegge, Sjoert
-
van der Hoorn, Anouk
-
Vinke, Saman
-
van Oostenbrugge, Robert J.
-
Flach, H. Zwenneke
-
Lingsma, Hester F.
-
Ghannouti, Naziha el
-
Sterrenberg, Martin
-
Pellikaan, Wilma
-
Sprengers, Rita
-
Elfrink, Marjan
-
Simons, Michelle
-
Vossers, Marjolein
-
de Meris, Joke
-
Vermeulen, Tamara
-
Geerlings, Annet
-
van Vemde, Gina
-
Simons, Tiny
-
Messchendorp, Gert
-
Nicolaij, Nynke
-
Bongenaar, Hester
-
Bodde, Karin
-
Kleijn, Sandra
-
Lodico, Jasmijn
-
Droste, Hanneke
-
Wollaert, Maureen
-
Verheesen, Sabrina
-
Jeurrissen, D.
-
Bos, Erna
-
Drabbe, Yvonne
-
Sandiman, Michelle
-
Aaldering, Nicoline
-
Zweedijk, Berber
-
Vervoort, Jocova
-
Ponjee, Eva
-
Romviel, Sharon
-
Kanselaar, Karin
-
Barning, Denn
-
Venema, Esmee
-
Chalos, Vicky
-
Geuskens, Ralph R.
-
van Straaten, Tim
-
Ergezen, Saliha
-
Harmsma, Roger R.M.
-
Muijres, Daan
-
de Jong, Anouk
-
Berkhemer, Olvert A.
-
Boers, Anna M.M.
-
Huguet, J.
-
Groot, P.F.C.
-
Mens, Marieke A.
-
van Kranendonk, Katinka R.
-
Treurniet, Kilian M.
-
Tolhuisen, Manon L.
-
Alves, Heitor
-
Weterings, Annick J.
-
Kirkels, Eleonora L.F.
-
Schupp, Lieve M.
-
Voogd, Eva J.H.F.
-
Collette, Sabine
-
Konduri, Praneeta R.
-
Prasetya, Haryadi
-
Arrarte-Terreros, Nerea
-
Ramos, Lucas A.
Show more…
Published in:
- Stroke. - Ovid Technologies (Wolters Kluwer Health). - 2020, vol. 51, no. 12, p. 3742-3745
English
Background and Purpose:
Ischemic brain tissue damage in patients with acute ischemic stroke, as measured by the Alberta Stroke Program Early CT Score (ASPECTS) may be more impactful in older than in younger patients, although this has not been studied. We aimed to investigate a possible interaction effect between age and ASPECTS on functional outcome in acute ischemic stroke patients undergoing endovascular treatment, and compared reperfusion benefit across age and ASPECTS subgroups.
Methods:
Patients with ischemic stroke from the MR CLEAN Registry (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands; March 2014–November 2017) were included. Multivariable ordinal logistic regression was performed to obtain effect size estimates (adjusted common odds ratio) on functional outcome (modified Rankin Scale score) for continuous age and granular ASPECTS, with a 2-way multiplicative interaction term (age×ASPECTS). Outcomes in four patient subgroups based on age (< versus ≥ median age [71.8 years]) and baseline ASPECTS (6–10 versus 0–5) were assessed.
Results:
We included 3279 patients. There was no interaction between age and ASPECTS on modified Rankin Scale (
P
=0.925). The highest proportion of modified Rankin Scale 5 to 6 was observed in patients >71.8 years with baseline ASPECTS 0 to 5 (68/107, 63.6%). There was benefit of reperfusion in all age-ASPECTS subgroups. Although the adjusted common odds ratio was lower in patients >71.8 years with ASPECTS 0 to 5 (adjusted common odds ratio, 1.60 [95% CI, 0.66–3.88], n=110), there was no significant difference from the main effect (
P
=0.299).
Conclusions:
Although the proportion of poor outcomes following endovascular treatment was highest in older patients with low baseline ASPECTS, outcomes did not significantly differ from the main effect. These results do not support withholding endovascular treatment based n a combination of high age and low ASPECTS.
-
Language
-
-
Open access status
-
closed
-
Identifiers
-
-
Persistent URL
-
https://sonar.ch/global/documents/5677
Statistics
Document views: 25
File downloads: