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Cocaine unbalances endothelial tissue factor and tissue factor pathway inhibitor expression.
Journal article

Cocaine unbalances endothelial tissue factor and tissue factor pathway inhibitor expression.

  • 2006-03-07
Published in:
  • Journal of molecular and cellular cardiology. - 2006
Acute Disease
Aorta
Atherosclerosis
Cells, Cultured
Cocaine
Endothelial Cells
Endothelium, Vascular
Gene Expression Regulation
Heart Diseases
Humans
Lipoproteins
Myocardial Infarction
Thrombin
Thromboplastin
Vasoconstrictor Agents
English Cocaine consumption can lead to myocardial infarction. Tissue factor (TF) has been implicated in acute coronary syndromes, and the balance of TF and tissue factor pathway inhibitor (TFPI) determines initiation of thrombus formation. This study was designed to investigate the effect of cocaine on endothelial TF and TFPI expression. Cocaine (10(-8)-10(-5) mol/l) increased thrombin-induced TF expression by 24% at 10(-7) mol/l (P < 0.001) without affecting basal TF expression. In contrast, cocaine reduced endothelial TFPI expression by 47% at 10(-7) mol/l (P < 0.01). Moreover, thrombin impaired endothelial TFPI expression, and cocaine (10(-8) mol/l) further reduced TFPI expression by 33% as compared to thrombin (P < 0.02). These effects occur at cocaine concentrations usually present in plasma of consumers. Given the importance of TF in the pathogenesis of acute coronary syndromes, TF induction in conjunction with TFPI suppression may be relevant for the increased frequency of myocardial infarction observed in cocaine consumers.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/57163
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