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Bmp4 Promotes a Brown to White-like Adipocyte Shift.

  • Modica S Swiss Federal Institute of Technology, Department of Health Science, Institute of Food Nutrition and Health, Laboratory of Translational Nutrition Biology, Schwerzenbach 8603, Switzerland.
  • Straub LG Swiss Federal Institute of Technology, Department of Health Science, Institute of Food Nutrition and Health, Laboratory of Translational Nutrition Biology, Schwerzenbach 8603, Switzerland.
  • Balaz M Swiss Federal Institute of Technology, Department of Health Science, Institute of Food Nutrition and Health, Laboratory of Translational Nutrition Biology, Schwerzenbach 8603, Switzerland.
  • Sun W Swiss Federal Institute of Technology, Department of Health Science, Institute of Food Nutrition and Health, Laboratory of Translational Nutrition Biology, Schwerzenbach 8603, Switzerland.
  • Varga L Obesity section of Diabetes Laboratory, Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, 845 05 Bratislava, Slovakia; Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine and University Hospital, Comenius University, 811 02 Bratislava, Slovakia.
  • Stefanicka P Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine and University Hospital, Comenius University, 811 02 Bratislava, Slovakia.
  • Profant M Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine and University Hospital, Comenius University, 811 02 Bratislava, Slovakia.
  • Simon E Target Discovery Research, Boehringer Ingelheim Pharma, 88400 Biberach/Riss, Germany.
  • Neubauer H CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma, 88400 Biberach/Riss, Germany.
  • Ukropcova B Obesity section of Diabetes Laboratory, Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, 845 05 Bratislava, Slovakia; Institute of Pathophysiology, Faculty of Medicine, Comenius University, 811 02 Bratislava, Slovakia.
  • Ukropec J Obesity section of Diabetes Laboratory, Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, 845 05 Bratislava, Slovakia.
  • Wolfrum C Swiss Federal Institute of Technology, Department of Health Science, Institute of Food Nutrition and Health, Laboratory of Translational Nutrition Biology, Schwerzenbach 8603, Switzerland. Electronic address: christian-wolfrum@ethz.ch.
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  • 2016-08-16
Published in:
  • Cell reports. - 2016
Adipocytes, Brown
Adipocytes, White
Adipogenesis
Adipose Tissue, Brown
Adipose Tissue, White
Animals
Bone Morphogenetic Protein 4
Cell Differentiation
Cell Line, Transformed
Cyclic AMP
Diabetes Mellitus, Type 2
Gene Expression Regulation
Humans
Insulin Resistance
Male
Mesenchymal Stem Cells
Mice
Mice, Inbred C57BL
Peroxisome Proliferator-Activated Receptors
Rosiglitazone
Signal Transduction
Smad Proteins
Sterol Esterase
Thiazolidinediones
English While Bmp4 has a well-established role in the commitment of mesenchymal stem cells into the adipogenic lineage, its role in brown adipocyte formation and activity is not well defined. Here, we show that Bmp4 has a dual function in adipogenesis by inducing adipocyte commitment while inhibiting the acquisition of a brown phenotype during terminal differentiation. Selective brown adipose tissue overexpression of Bmp4 in mice induces a shift from a brown to a white-like adipocyte phenotype. This effect is mediated by Smad signaling and might be in part due to suppression of lipolysis, via regulation of hormone sensitive lipase expression linked to reduced Ppar activity. Given that we observed a strong correlation between BMP4 levels and adipocyte size, as well as insulin sensitivity in humans, we propose that Bmp4 is an important factor in the context of obesity and type 2 diabetes.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/57710
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