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Biofilm Matrixome: Extracellular Components in Structured Microbial Communities.

  • Karygianni L Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine University of Zurich, Zurich, Switzerland.
  • Ren Z Department of Orthodontics, Divisions of Pediatric Dentistry and Community of Oral Health, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
  • Koo H Department of Orthodontics, Divisions of Pediatric Dentistry and Community of Oral Health, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA; Center for Innovation and Precision Dentistry, University of Pennsylvania School of Dental Medicine, School of Engineering and Applied Sciences, Philadelphia, PA, USA.
  • Thurnheer T Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine University of Zurich, Zurich, Switzerland. Electronic address: thomas.thurnheer@zzm.uzh.ch.
  • 2020-07-15
Published in:
  • Trends in microbiology. - 2020
extracellular matrix
extracellular polymeric substances (EPSs)
microenvironments
polymicrobial biofilm
spatial organization
virulence
English Biofilms consist of microbial communities embedded in a 3D extracellular matrix. The matrix is composed of a complex array of extracellular polymeric substances (EPS) that contribute to the unique attributes of biofilm lifestyle and virulence. This ensemble of chemically and functionally diverse biomolecules is termed the 'matrixome'. The composition and mechanisms of EPS matrix formation, and its role in biofilm biology, function, and microenvironment are being revealed. This perspective article highlights recent advances about the multifaceted role of the 'matrixome' in the development, physical-chemical properties, and virulence of biofilms. We emphasize that targeting biofilm-specific conditions such as the matrixome could lead to precise and effective antibiofilm approaches. We also discuss the limited knowledge in the context of polymicrobial biofilms, and the need for more in-depth analyses of the EPS matrix in mixed communities that are associated with many human infectious diseases.
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  • English
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hybrid
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https://sonar.ch/global/documents/5782
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